Oxidative stress in Campylobacter jejuni: responses, resistance and regulation

被引:73
作者
Atack, John M. [2 ]
Kelly, David J. [1 ]
机构
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Sheffield, Dept Chem, Krebs Inst, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England
基金
英国生物技术与生命科学研究理事会;
关键词
catalase; Fur; hydrogen peroxide; methione sulfoxide reductase; peroxiredoxin; PerR; superoxide; superoxide dismutase; METHIONINE SULFOXIDE REDUCTASES; NEUTROPHIL-ACTIVATING PROTEIN; ALKYL HYDROPEROXIDE REDUCTASE; CYTOCHROME-C PEROXIDASE; HELICOBACTER-PYLORI; HYDROGEN-PEROXIDE; SUPEROXIDE-DISMUTASE; ESCHERICHIA-COLI; THIOL PEROXIDASE; COMMENSAL COLONIZATION;
D O I
10.2217/FMB.09.44
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Campylobacter jejuni is a major food-borne human pathogen that paradoxically is an oxygen-sensitive microaerophile, yet must resist the oxidative stresses encountered both in the host and in the environment. Recent studies suggest that, perhaps surprisingly, C. jejuni contains a wide range of enzymes involved in oxidative stress defense, and this review focuses on the properties and roles of these proteins, Although the mechanisms of gene regulation are still poorly understood in C. jejuni, several regulators of the oxidative stress response have been identified and their properties are discussed here, We suggest that future studies should be directed towards identifying the role of additional and less well characterized components involved in oxidative stress resistance, as well as providing a more complete picture of the underlying sensing and regulatory mechanisms.
引用
收藏
页码:677 / 690
页数:14
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