Viruses and interferon: A fight for supremacy

被引：954
作者：
Katze, MG [1 ]
He, YP
Gale, M
机构：
[1] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
[2] Univ Texas, SW Med Ctr, Dallas, TX 75390 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri888
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The action of interferons (IFNs) on virus-infected cells and surrounding tissues elicits an antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated genes. In turn, viruses encode mechanisms to counteract the host response and support efficient viral replication, thereby minimizing the therapeutic antiviral power of IFNs. In this review, we discuss the interplay between the IFN system and four medically important and challenging viruses influenza, hepatitis C, herpes simplex and vaccinia - to highlight the diversity of viral strategies. Understanding the complex network of cellular antiviral processes and virus-host interactions should aid in identifying new and common targets for the therapeutic intervention of virus infection. This effort must take advantage of the recent developments in functional genomics, bioinformatics and other emerging technologies.
引用
收藏
页码：675 / 687
页数：13
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