HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells

被引：5

作者：

Schott, Sonia ^{[1
]}

Ramos, Fabien ^{[1
]}

Coustham, Vincent ^{[1
]}

Palladino, Francesca ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, Mol & Cellular Biol Lab, UNIR5239, F-69007 Lyon, France

来源：

GENETICS | 2009年 / 181卷 / 02期

关键词：

C-ELEGANS; FATE SPECIFICATION; LIN-35; RB; PROTEINS; GENES; COMPLEX; ANTAGONIZE; ACTS; TRANSCRIPTION; LIN-39/HOX;

D O I：

10.1534/genetics.108.089276

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl/2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.

引用

页码：797 / 801

页数：5

共 28 条

[1] Two C-elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development [J].

Andersen, Erik C. ;

Horvitz, H. Robert .

DEVELOPMENT, 2007, 134 (16) :2991-2999

[2] A new class of C-elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of ras signaling [J].

Ceol, CJ ;

Horvitz, HR .

DEVELOPMENTAL CELL, 2004, 6 (04) :563-576

[3] dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C-elegans vulval development [J].

Ceol, CJ ;

Horvitz, HR .

MOLECULAR CELL, 2001, 7 (03) :461-473

[4]

Chen Z, 2001, DEVELOPMENT, V128, P4911

[5] C-elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification [J].

Chen, Z ;

Han, M .

CURRENT BIOLOGY, 2001, 11 (23) :1874-1879

[6] The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development [J].

Coustham, Vincent ;

Bedet, Cecile ;

Monier, Karine ;

Schott, Sonia ;

Karali, Marianthi ;

Palladino, Francesca .

DEVELOPMENTAL BIOLOGY, 2006, 297 (02) :308-322

[7] A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development [J].

Couteau, F ;

Guerry, F ;

Müller, F ;

Palladino, F .

EMBO REPORTS, 2002, 3 (03) :235-241

[8] SynMuv genes redundantly inhibit lin-31EGF expression to prevent inappropriate vulval induction in C-elegans [J].

Cui, Mingxue ;

Chen, Jun ;

Myers, Toshia R. ;

Hwang, Byung Joon ;

Sternberg, Paul W. ;

Greenwald, Iva ;

Han, Min .

DEVELOPMENTAL CELL, 2006, 10 (05) :667-672

[9]

DURR A, 2004, PLOS BIOL, V2, pE334

[10]

FERGUSON EL, 1989, GENETICS, V123, P109

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