Enamine-based aldol organocatalysis in water: Are they really "all wet"?

被引：280
作者：
Brogan, Andrew P.
Dickerson, Tobin J.
Janda, Kim D.
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Immunol, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Worm Inst Res & Med, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 48期
关键词：
aldol reaction; asymmetric catalysis; green chemistry; organocatalysis;
D O I：
10.1002/anie.200601392
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Reactions with, in, or on water? Despite claims to the contrary, few examples of truly aqueous organocatalysis have been reported. Close examination of the data from recent reports reveals that these reactions likely occur in concentrated organic phases. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8100 / 8102
页数：3
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