Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

被引：20

作者：

Facon, T ^{[1
]}

Jouet, JP ^{[1
]}

NoelWalter, MP ^{[1
]}

Bloget, F ^{[1
]}

Bauters, F ^{[1
]}

Janin, A ^{[1
]}

机构：

[1] CHRU,HOP CALMETTE,SERV ANAT PATHOL C,LILLE,FRANCE

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 20卷 / 06期

关键词：

acute graft-versus-host disease; macrophage; TNF-alpha;

D O I：

10.1038/sj.bmt.1700912

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking. preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha, The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

引用

页码：511 / 515

页数：5

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