Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones

被引：178

作者：

Fu, Niankai ^{[1
,2
,3
]}

Li, Longji ^{[1
,2
]}

Yang, Qi ^{[1
,2
]}

Luo, Sanzhong ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Dept Chem, Beijing 10049, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 08期

关键词：

C-H FUNCTIONALIZATION; BETA-KETOCARBONYLS; ANODIC-OXIDATION; CROSS; ARYLATION; ALDEHYDES; BONDS; ACTIVATION; AMINATION; STRATEGY;

D O I：

10.1021/acs.orglett.7b00746

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric electrochemical C-H functionalization of simple ketones has been developed. The transformatibn is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This Metal- and oxidant-free method furnishes diverse Cl-alkylated tetrahydroisoquinolines in high yields and with excellent enantioselectivities under very mild conditions.

引用

页码：2122 / 2125

页数：4

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