Biomechanical and histological comparison of the influence of oestrogen deficient state on tendon healing potential in rats

被引：30

作者：

Circi, Esra ^{[1
,2
]}

Akpinar, Sercan ^{[2
]}

Balcik, Cenk ^{[3
]}

Bacanli, Didem ^{[4
]}

Guven, Gulnur ^{[5
]}

Akgun, Rahmi Can ^{[2
]}

Tuncay, Ismail Cengiz ^{[2
]}

机构：

[1] Baskent Univ, Tip Fak Hastanesi, TR-06490 Ankara, Turkey

[2] Baskent Univ, Fac Med, Dept Orthopaed & Traumatol, TR-06490 Ankara, Turkey

[3] Baskent Univ, Fac Engn, Dept Mech Engn, TR-06490 Ankara, Turkey

[4] Baskent Univ, Expt Res Ctr, TR-06490 Ankara, Turkey

[5] Baskent Univ, Fac Med, Dept Pathol, TR-06490 Ankara, Turkey

来源：

INTERNATIONAL ORTHOPAEDICS | 2009年 / 33卷 / 05期

关键词：

ANTERIOR CRUCIATE LIGAMENT; IN-VIVO; INJURY; REPAIR; GENDER; KNEE;

D O I：

10.1007/s00264-009-0778-1

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Thirty-six female Sprague-Dawley rats were divided into two groups: oophrectomised (oestrogen deficient) rats and sham operated (oestrogen maintained) rats. Rats were sacrificed at six, ten, and 14 weeks. The rats were randomly chosen to have biomechanical evaluation on one side and histological evaluation on the other. Biomechanical testing was performed on an Instron machine to measure peak load. Histological sections were evaluated for cell proliferation, collagen-fibre organisation, fibroblast density, angiogenesis, inflammatory cells, chondroid and osseous metaplasia. Compared with the sham operated group, the oophrectomised group showed a lesser average maximum stress (42.9 N/m(2) versus 33.7 N/m(2)) at six weeks, which was significant (p<.05). Succeeding weeks showed no significant biomechanical differences between the two groups. The sham operated group showed greater inflammatory response, which was statistically significant (p<0.05), and also revealed greater cell proliferation and density. The results of this study revealed that endogenous oestrogen may improve healing of the Achilles tendon in rats.

引用

页码：1461 / 1466

页数：6

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