Phthalate metabolites in urine of Chinese young adults: Concentration, profile, exposure and cumulative risk assessment

被引：101

作者：

Gao, Chong-Jing ^{[1
]}

Liu, Li-Yan ^{[1
]}

Ma, Wan-Li ^{[1
]}

Ren, Nan-Qi ^{[1
]}

Guo, Ying ^{[2
]}

Zhu, Ning-Zheng ^{[1
]}

Jiang, Ling ^{[3
]}

Li, Yi-Fan ^{[1
]}

Kannan, Kurunthachalam ^{[2
]}

机构：

[1] Harbin Inst Technol, Sch Municipal & Environm Engn, State Key Lab Urban Water Resource & Environm, Int Joint Res Ctr Persistent Toxic Subst, Harbin 150090, Peoples R China

[2] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Wadsworth Ctr,New York State Dept Hlth, Albany, NY 12201 USA

[3] Harbin Inst Technol, Campus Hosp 2, Harbin 150090, Peoples R China

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2016年 / 543卷

基金：

中国国家自然科学基金;

关键词：

Phthalates; Urine; Human exposure; Cumulative risk assessment; China; PERSONAL CARE PRODUCTS; DI(2-ETHYLHEXYL) PHTHALATE; PREGNANT-WOMEN; GENERAL-POPULATION; INDOOR DUST; DEHP; PARABENS; DIESTERS; ESTERS; SERUM;

D O I：

10.1016/j.scitotenv.2015.11.005

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalates are widely used in consumer products. People are frequently exposed to phthalates due to their applications in daily life. In this study, 14 phthalate metabolites were analyzed in 108 urine samples collected from Chinese young adults using high-performance liquid chromatography-tandem mass spectrometry. The total concentrations of 14 phthalate metabolites ranged from 71.3 to 2670 ng/mL, with the geometric mean concentration of 306 ng/mL. mBP and miBP were the two most abundant compounds, accounting for 48% of the total concentrations. Principal component analysis suggested two major sources of phthalates: one dominated by the DEHP metabolites and one by the group of mCPP, mBP and miBP metabolites. The estimated daily intakes of DMP, DEP, DBP, DiBP and DEHP were 1.68, 2.14, 4.12, 3.52 and 1.26-2.98 mu g/kg-bw/day, respectively. In a sensitivity analysis, urinary concentration and body weight were the most influential variables for human exposure estimation. Furthermore, cumulative risk for hazard quotient (HQ) and hazard index (HI) were evaluated. Nearly half of Chinese young adults had high HI values exceeding the safe threshold. This is the first study on the occurrence and human exposure to urinary phthalate metabolites with Chinese young adults. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：19 / 27

页数：9

共 81 条

[1] METABOLISM OF DIETHYLHEXYL PHTHALATE BY RATS ISOLATION AND CHARACTERIZATION OF URINARY METABOLITES [J].