Estrogen metabolism during pregnancy

被引：9

作者：

Kovacs Krisztian ^{[1
]}

Vasarhelyi Barna ^{[1
]}

Gyarmati Bela ^{[2
]}

Karvaly Gellert ^{[1
]}

机构：

[1] Semmelweis Egyet, Altalanos Orvostud Kar, Lab Med Int, Budapest, Hungary

[2] Uzsoki Utcai Korhaz, Szuleszet Nogyogyaszati Osztaly, Budapest, Hungary

来源：

ORVOSI HETILAP | 2019年 / 160卷 / 26期

关键词：

pregnancy; placenta; estrogen metabolism; preeclampsia; estriol; CATECHOL-O-METHYLTRANSFERASE; HUMAN PLACENTA; METHYLATION; 2-METHOXYOESTRADIOL; 2-METHOXYESTRADIOL; PREECLAMPSIA; MODULATION; EXPRESSION; BIOMARKERS; CANCER;

D O I：

10.1556/650.2019.31433

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The extensive metabolism of estrogen hormones, where oxidized forms, structural isomers and conjugated products appear in many tissues locally as well as in systemic circulation, is believed to be associated with a number of diseases. Targeted estrogen metabolomic studies have been largely associated with postmenopausal, malignant advert immune conditions. Although the role of estriol in maintaining pregnancy and the biological activity of estrogen metabolites is known, a relatively small number of publications have addressed the formation and transformation of these compounds during pregnancy. The aim of this study is to present in detail the formation and progression of estrogen metabolites during pregnancy and to summarize the knowledge of their role in undesirable processes occurring during gestation.

引用

页码：1007 / 1014

页数：8

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