Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

被引：12

作者：

Shu, Xinyu ^{[1
,2
,3
]}

Li, Ning ^{[1
,2
,3
]}

Wu, Yi ^{[1
,2
,3
]}

Li, Wang ^{[1
,2
,3
]}

Zhang, Xiaoyu ^{[1
,2
,3
]}

Li, Peiwen ^{[1
,2
]}

Lu, Dongyuan ^{[1
,2
,3
]}

Lu, Shouqin ^{[1
,2
,3
]}

Long, Mian ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China

来源：

ACTA MECHANICA SINICA | 2021年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Liver sinusoidal endothelial cell; Shear stress; Mechanical stretch; Extracellular matrix; Stiffness; MAGNETIC-RESONANCE ELASTOGRAPHY; PORTAL-VEIN EMBOLIZATION; SHEAR-STRESS; RAT-LIVER; ACTIN CYTOSKELETON; HEPATIC SINUSOIDS; PRIMARY CILIUM; CYCLE EXIT; F-ACTIN; HEDGEHOG;

D O I：

10.1007/s10409-021-01057-3

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed.

引用

页码：201 / 217

页数：17

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