Chronic Periodontitis Does Not Impact Serum Levels of Prostate-specific Antigen

被引：10

作者：

Kruck, Stephan ^{[1
]}

Hennenlotter, Joerg ^{[1
]}

Amend, Bastian ^{[1
]}

Geiger, Maya ^{[1
]}

Filipova, Elitsa ^{[1
]}

Neumann, Tim ^{[1
]}

Stuehler, Viktoria ^{[1
]}

Schubert, Tina ^{[1
]}

Todenhoefer, Tilman ^{[1
]}

Rausch, Steffen ^{[1
]}

Huettig, Fabian ^{[1
,2
]}

Stenzl, Arnulf ^{[1
]}

Bedke, Jens ^{[1
]}

机构：

[1] Eberhard Karls Univ Tubingen, Dept Urol, Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Ctr Dent Oral Med & Maxillofacial Surg, Dept Prosthodont, Tubingen, Germany

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 06期

关键词：

Chronic periodontitis; inflammation; mass screening; prostate cancer; prostate-specific antigen; HEALTH-PROFESSIONALS; CANCER MORTALITY; UNITED-STATES; FOLLOW-UP; DISEASE; MEN; PSA; RISK; ASSOCIATION; ADULTS;

D O I：

10.21873/anticanres.11675

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Chronic periodontitis (CP) has already been associated with altered PSA values in men undergoing biopsy. This study addressed the impact of CP treatment on PSA screening. Patients and Methods: Fifty-two asymptomatic men presenting for CP treatment were prospectively enrolled. Total (t) PSA, free (f) PSA and % PSA were determined (n= 47) before and after therapy. Pre-and post-therapy values were correlated pairwise regarding patients and dental characteristics. Results: Median age was 54 years (SD=+/- 7.7 years) and mean tPSA was 1.3 ng/ml (+/- 1.9 ng/ml). tPSA and fPSA correlated linearly and positively with age (p< 0.002). After stratification by age, tPSA/fPSA remained significantly lower in smokers (p< 0.05). No other patient or dental factor was associated with tPSA, fPSA, % PSA. CP therapy had no effect on PSA reduction and did not affect indication for biopsy. Conclusion: The potential influence of CP on PSA testing seems to be excludable in asymptomatic men.

引用

页码：3163 / 3167

页数：5

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