Flow biocatalysis 101: design, development and applications

被引：74
作者：
Benitez-Mateos, Ana I. [1 ]
Contente, Martina L. [1 ]
Roura Padrosa, David [1 ]
Paradisi, Francesca [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, Bern, Switzerland
来源：
REACTION CHEMISTRY & ENGINEERING | 2021年 / 6卷 / 04期
关键词：
D O I：
10.1039/d0re00483a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The integration of enzyme-catalyzed reactions in flow systems has been boosted during the last few years. Nowadays, biocatalysis is officially recognized as a tool to increase reaction specificity and sustainability, however applications are sometimes characterized by low productivity. A logical step to improve the performance of biocatalytic reactions is represented by the combination of enzymes and flow facilities. This tutorial review aims at introducing the key concepts of flow biocatalysis, guiding the reader through its advantages and highlighting the current trends in the field to encourage innovative applications of enzymes in flow reactors. Experimental cases are also presented and discussed as a troubleshooting guide for development of flow biocatalytic processes.
引用
收藏
页码：599 / 611
页数：13
相关论文
共 59 条
  • [1] Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis
    Agostino, Fletcher J.
    Krylov, Sergey N.
    [J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2015, 72 : 68 - 79
  • [2] Enzyme engineering: Reshaping the biocatalytic functions
    Ali, Misha
    Ishqi, Hassan Mubarak
    Husain, Qayyum
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2020, 117 (06) : 1877 - 1894
  • [3] Flow distribution in different microreactor scale-out geometries and the effect of manufacturing tolerances and channel blockage
    Amador, C
    Gavriilidis, A
    Angeli, P
    [J]. CHEMICAL ENGINEERING JOURNAL, 2004, 101 (1-3) : 379 - 390
  • [4] Green Chemistry: Principles and Practice
    Anastas, Paul
    Eghbali, Nicolas
    [J]. CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) : 301 - 312
  • [5] Directed Evolution: Bringing New Chemistry to Life
    Arnold, Frances H.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (16) : 4143 - 4148
  • [6] Why We Need Continuous Pharmaceutical Manufacturing and How to Make It Happen
    Badman, Clive
    Cooney, Charles L.
    Florence, Alastair
    Konstantinov, Konstantin
    Krumme, Markus
    Mascia, Salvatore
    Nasr, Moheb
    Trout, Bernhardt L.
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (11) : 3521 - 3523
  • [7] The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds
    Bana, Peter
    Orkenyi, Robert
    Lovei, Klara
    Lako, Agnes
    Turos, Gyorgy Istvan
    Eles, Janos
    Faigl, Ferenc
    Greiner, Istvan
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (23) : 6180 - 6189
  • [8] Berglund P., 2006, CHEMBIOCHEM, V7, P1280, DOI [10.1002/cbic.200600269, DOI 10.1002/CBIC.200600269]
  • [9] Characterization and evaluation of immobilized enzymes for applications in flow reactors
    Bolivar, Juan M.
    Lopez-Gallego, Fernando
    [J]. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, 2020, 25
  • [10] Process intensification for O2-dependent enzymatic transformations in continuous single-phase pressurized flow
    Bolivar, Juan M.
    Mannsberger, Alexander
    Thomsen, Malene S.
    Tekautz, Guenter
    Nidetzky, Bernd
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2019, 116 (03) : 503 - 514
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