Assembly of Viral Membrane Proteins

被引：38

作者：

Krueger, J. ^{[1
]}

Fischer, W. B. ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Biophoton, Sch Med Sci & Engn, Taipei 112, Taiwan

来源：

JOURNAL OF CHEMICAL THEORY AND COMPUTATION | 2009年 / 5卷 / 09期

关键词：

INFLUENZA-A VIRUS; M2 PROTON CHANNEL; MOLECULAR-DYNAMICS SIMULATION; ION-CHANNEL; TRANSMEMBRANE DOMAIN; H+ CHANNEL; HIV-1; VPU; 2-STAGE MODEL; RNA SEGMENT-7; IDENTIFICATION;

D O I：

10.1021/ct900185n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The generation of computational models is an alternative route to obtain reliable structures for the oligomeric state of membrane proteins. A strategy has been developed to search the conformational space of all possible assemblies in a reasonable time, taking symmetry considerations into account. The methodology tested on M2 from influenza A, shows an excellent agreement with established structures. For Vpu from HIV-1 a series of conformational distinct structures are proposed. For the first time a structural model for a fully assembled transmembrane part of 3a from SARS-CoV is proposed.

引用

页码：2503 / 2513

页数：11

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