Chemokine receptors and neural function

被引：45

作者：

Cho, C

Miller, RJ

机构：

[1] Northwestern Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Chicago, IL 60611 USA

[2] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2002年 / 8卷 / 06期

关键词：

calcium; GPCR; neuronal survival; neurotransmission; signal transduction;

D O I：

10.1080/13550280290101003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Numerous studies have demonstrated that chemokines play an integral role in diseases marked by inflammation. Recently, it has also been shown that chemokines and their receptors are widely expressed in the central nervous system by all types of cells, including neurons. The functions of neuronal chemokine receptors have yet to be fully defined. However, there are indications that neuronal chemokine receptors play an integral role in the development of the nervous system, in the regulation of neuronal excitability and in the signal transduction pathways that regulate neuronal survival. This review explores these topics and discusses the overall impact that chemokines may have on neuronal function.

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收藏

页码：573 / 584

页数：12

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