Glycosphingolipids and drug resistance

被引：83
作者：
Gouaze-Andersson, Valerie [1 ]
Cabot, Myles C. [1 ]
机构：
[1] St Johns Hlth Ctr, Dept Expt Therapeut, John Wayne Canc Inst, Santa Monica, CA 90404 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 12期
基金：
美国国家卫生研究院;
关键词：
multidrug resistance; glycosphingolipids; glucosylceramide synthase; P-glycoprotein;
D O I：
10.1016/j.bbamem.2006.08.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest. In addition to cancer, the ABC transporter proteins are active in diseases such as malaria and leishmaniasis. A recent renaissance in lipid metabolism, specifically ceramide and sphingolipids, has fueled research and provided insight into the role of glycosphingolipids in multidrug resistance. This article reviews current knowledge on ceramide, glucosylceramide synthase and cerebrosides, and the relationship of these lipids to cellular response to anticancer agents. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：2096 / 2103
页数：8
相关论文
共 104 条
  • [11] Chevillard S, 1996, CANCER, V77, P292, DOI 10.1002/(SICI)1097-0142(19960115)77:2<292::AID-CNCR11>3.0.CO
  • [12] 2-X
  • [13] OVEREXPRESSION OF A TRANSPORTER GENE IN A MULTIDRUG-RESISTANT HUMAN LUNG-CANCER CELL-LINE
    COLE, SPC
    BHARDWAJ, G
    GERLACH, JH
    MACKIE, JE
    GRANT, CE
    ALMQUIST, KC
    STEWART, AJ
    KURZ, EU
    DUNCAN, AMV
    DEELEY, RG
    [J]. SCIENCE, 1992, 258 (5088) : 1650 - 1654
  • [14] Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation
    Deng, W
    Li, RX
    Guerrera, M
    Liu, YH
    Ladisch, S
    [J]. GLYCOBIOLOGY, 2002, 12 (03) : 145 - 152
  • [15] Influence of cellular ganglioside depletion on tumor formation
    Deng, W
    Li, RX
    Ladisch, S
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (11) : 912 - 917
  • [16] Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells
    di Bartolomeo, S
    Spinedi, A
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (01) : 269 - 274
  • [17] Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis
    Di Sano, F
    Di Bartolomeo, S
    Fazi, B
    Fiorentini, C
    Matarrese, P
    Spinedi, A
    Piacentini, M
    [J]. CELL DEATH AND DIFFERENTIATION, 2002, 9 (06) : 693 - 695
  • [18] Differential expression of sphingolipids in P-glycoprotein or multidrug resistance-related protein 1 expressing human neuroblastoma cell lines
    Dijkhuis, AJ
    Douwes, J
    Kamps, W
    Sietsma, H
    Kok, JW
    [J]. FEBS LETTERS, 2003, 548 (1-3): : 28 - 32
  • [19] The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids
    Eckford, PDW
    Sharom, FJ
    [J]. BIOCHEMICAL JOURNAL, 2005, 389 : 517 - 526
  • [20] Goldkorn T, 1997, ADV EXP MED BIOL, V400, P461
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