Glycosphingolipids and drug resistance

被引：83

作者：

Gouaze-Andersson, Valerie ^{[1
]}

Cabot, Myles C. ^{[1
]}

机构：

[1] St Johns Hlth Ctr, Dept Expt Therapeut, John Wayne Canc Inst, Santa Monica, CA 90404 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 12期

基金：

美国国家卫生研究院;

关键词：

multidrug resistance; glycosphingolipids; glucosylceramide synthase; P-glycoprotein;

D O I：

10.1016/j.bbamem.2006.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest. In addition to cancer, the ABC transporter proteins are active in diseases such as malaria and leishmaniasis. A recent renaissance in lipid metabolism, specifically ceramide and sphingolipids, has fueled research and provided insight into the role of glycosphingolipids in multidrug resistance. This article reviews current knowledge on ceramide, glucosylceramide synthase and cerebrosides, and the relationship of these lipids to cellular response to anticancer agents. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：2096 / 2103

页数：8

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