Percutaneous computed tomography-guided iodine-125 seeds implantation for unresectable pancreatic cancer

被引：40
作者：
Liu, B. [1 ]
Zhou, T. [2 ]
Geng, J. [3 ]
Zhang, F. [4 ,5 ]
Wang, J. [6 ]
Li, Y. [1 ]
机构：
[1] Shandong Univ, Hosp 2, Dept Intervent Med, Jinan, Shandong, Peoples R China
[2] Shandong Univ, Coll Med, Jinan, Shandong, Peoples R China
[3] Weihai Municipal Hosp, Dept Hepatobiliary Surg, Jinan, Shandong, Peoples R China
[4] Sun Yat Sen Univ, Ctr Canc, Dept Med Imaging & Intervent Radiol, Guangzhou 510275, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
[6] Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100871, Peoples R China
来源：
INDIAN JOURNAL OF CANCER | 2015年 / 52卷 / 06期
关键词：
Brachytherapy; iodine; pancreas cancer; radioisotopes; LOCALIZED PROSTATE-CANCER; BRACHYTHERAPY; TOXICITY; CRITERIA; THERAPY;
D O I：
10.4103/0019-509X.172517
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: To examine the safety and clinical efficacy of computed tomography (CT)-guided radioactive iodine-125 (I-125) seeds implantation for patients with unresectable pancreatic cancer. MATERIALS AND METHODS: A group of 26 patients with pathologically confirmed unresectable pancreatic cancer underwent percutaneous CT-guided I-125 seeds implantation. Part of them received transarterial chemotherapy and/or percutaneous transhepatic cholangial drainage before or after seeds implantation. The primary endpoints were the objective response rates, local control rates, and overall survival. RESULTS: CT scan 2 months after treatment revealed complete response (CR) in 8 patients, partial response (PR) in 9 patients. Overall response rate (CR + PR) is 65.38%. Local control rate was 88.46%. Median survival of the whole group was 15.3 months, whereas for Stage Ill and IV was 17.6 and 9.1 months, respectively. The estimated 1-year survival was 30.77%. CONCLUSIONS: We consider CT-guided I-125 seeds implantation as a safe, effective, uncomplicated treatment for unresectable pancreatic cancer.
引用
收藏
页码：E69 / E74
页数：6
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