Waves of resistance: Staphylococcus aureus in the antibiotic era

被引：1877
作者：
Chambers, Henry F. [1 ]
DeLeo, Frank R. [2 ]
机构：
[1] Univ Calif San Francisco, Dept Med, San Francisco Gen Hosp, Div Infect Dis, San Francisco, CA 94110 USA
[2] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 09期
基金：
美国国家卫生研究院;
关键词：
PANTON-VALENTINE LEUKOCIDIN; CASSETTE CHROMOSOME MEC; BLOOD-STREAM INFECTIONS; METHICILLIN-RESISTANT; UNITED-STATES; MOLECULAR EPIDEMIOLOGY; NASAL COLONIZATION; IN-VITRO; VIRULENCE DETERMINANT; MULTIDRUG-RESISTANT;
D O I：
10.1038/nrmicro2200
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Staphylococcus aureus is notorious for its ability to become resistant to antibiotics. Infections that are caused by antibiotic-resistant strains often occur in epidemic waves that are initiated by one or a few successful clones. Methicillin-resistant S. aureus (MRSA) features prominently in these epidemics. Historically associated with hospitals and other health care settings, MRSA has now emerged as a widespread cause of community infections. Community or community-associated MRSA (CA-MRSA) can spread rapidly among healthy individuals. Outbreaks of CA-MRSA infections have been reported worldwide, and CA-MRSA strains are now epidemic in the United States. Here, we review the molecular epidemiology of the epidemic waves of penicillin-and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA.
引用
收藏
页码：629 / 641
页数：13
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