Suppression of ongoing experimental allergic encephalomyelitis in DA rats by novel peptide drug, structural part of human myelin basic protein 46-62

被引：10

作者：

Belogurov, A. A., Jr. ^{[1
,4
]}

Zargarova, T. A. ^{[2
]}

Turobov, V. I. ^{[2
]}

Novikova, N. I. ^{[2
]}

Favorova, O. O. ^{[3
]}

Ponomarenko, N. A. ^{[1
]}

Gabibov, A. G. ^{[1
,4
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[2] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Pushchino Branch, Pushchino 142290, Russia

[3] Cardiol Res Ctr, Inst Expt Cardiol, Moscow 121552, Russia

[4] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia

来源：

AUTOIMMUNITY | 2009年 / 42卷 / 04期

关键词：

Experimental allergic encephalomyelitis; myelin basic protein; multiple sclerosis; DA rats; Copaxone (R); EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ORAL GLATIRAMER ACETATE; MULTIPLE-SCLEROSIS; AUTOANTIBODIES; DEGRADATION;

D O I：

10.1080/08916930902832090

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously, we demonstrated that autoantibodies (AAb) in multiple sclerosis ( MS) reveal site-specific binding and cleavage toward myelin basic protein (MBP) epitope library. We have found several fragments of MBP immunodominant in terms of AAb binding. Here, we applied these peptides to DA rats with induced protracted relapsing experimental allergic encephalomyelitis (EAE) most closely related to MS. DA rats with EAE induced by syngenic spinal cord homogenate in complete Freund's adjuvant were treated by nasal route with human MBP 46-62, 81-102, 124-139, 147-170, and Copaxone (R). MBP 124-139 and 147-170 displayed only mild therapeutic effects but MBP 46-62 significantly reduced EAE, reflected by lower clinical scores and shorter EAE duration compared to controls.

引用

页码：362 / 364

页数：3

共 9 条

[1] Recognition and degradation of myelin basic protein peptides by serum autoantibodies: Novel biomarker for multiple sclerosis [J].

Belogurov, Alexey A., Jr. ;

Kurkova, Inna N. ;

Friboulet, Alain ;

Thomas, Daniel ;

Misikov, Viktor K. ;

Zakharova, Maria Yu. ;

Suchkov, Sergey V. ;

Kotov, Sergey V. ;

Alehin, Alexander I. ;

Avalle, Berangere ;

Souslova, Ekaterina A. ;

Morse, Herbert C., III ;

Gabibov, Alexander G. ;

Pononlarenko, Natalia A. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (02) :1258-1267

[2] Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event [J].

Berger, T ;

Rubner, P ;

Schautzer, F ;

Egg, R ;

Ulmer, H ;

Mayringer, I ;

Dilitz, E ;

Deisenhammer, F ;

Reindl, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (02) :139-145

[3] Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study [J].

Filippi, M ;

Wolinsky, JS ;

Comi, G .

LANCET NEUROLOGY, 2006, 5 (03) :213-220

[4] Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant [J].

Lorentzen, JC ;

Issazadeh, S ;

Storch, M ;

Mustafa, MI ;

Lassman, H ;

Linington, C ;

Klareskog, L ;

Olsson, T .

JOURNAL OF NEUROIMMUNOLOGY, 1995, 63 (02) :193-205

[5] Focus on research: The B cell - Old player, new position on the team [J].

McFarland, Henry F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (07) :664-665

[6] Catalytic activity of autoantibodies toward myelin basic protein correlates with the scores on the multiple sclerosis expanded disability status scale [J].

Ponomarenko, NA ;

Durova, OM ;

Vorobiev, II ;

Belogurov, AA ;

Telegin, GB ;

Suchkov, SV ;

Misikov, VK ;

Morse, HC ;

Gabibov, AG .

IMMUNOLOGY LETTERS, 2006, 103 (01) :45-50

[7] Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen [J].

Ponomarenko, NA ;

Durova, OM ;

Vorobiev, II ;

Belogurov, AA ;

Kurkova, IN ;

Petrenko, AG ;

Telegin, GB ;

Suchkov, SV ;

Kiselev, SL ;

Lagarkova, MA ;

Govorun, VM ;

Serebryakova, MV ;

Avalle, R ;

Tornatore, P ;

Karavanov, A ;

Morse, HC ;

Thomas, D ;

Friboulet, A ;

Gabibov, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (02) :281-286

[8] Oral glatiramer acetate in experimental autoimmune encephalomyelitis - Clinical and immunological studies [J].

Teitelbaum, D ;

Aharoni, R ;

Klinger, E ;

Kreitman, R ;

Raymond, E ;

Malley, A ;

Shofti, R ;

Sela, M ;

Arnon, R .

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION, 2004, 1029 :239-249

[9] Suppression of ongoing experimental allergic encephalomyelitis (EAE) in Lewis rats: synergistic effects of myelin basic protein (MBP) peptide 68-86 and IL-4 [J].

Xu, LY ;

Huang, YM ;

Yang, JS ;

Van der Meide, PH ;

Link, H ;

Xiao, BG .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 120 (03) :526-531

← 1 →