CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo

被引：12

作者：

Israel, Laura ^{[1
]}

Gluck, Anton ^{[1
]}

Berger, Marjorie ^{[2
]}

Coral, Marine ^{[1
]}

Ceci, Melanie ^{[1
]}

Unterreiner, Adeline ^{[1
]}

Rubert, Joelle ^{[1
]}

Bardet, Maureen ^{[1
]}

Ginster, Stefanie ^{[1
]}

Golding-Ochsenbein, Alexandra M. ^{[3
]}

Martin, Kea ^{[1
]}

Hoyler, Thomas ^{[1
]}

Calzascia, Thomas ^{[1
]}

Wieczorek, Grazyna ^{[1
]}

Hillenbrand, Rainer ^{[4
]}

Ferretti, Stephane ^{[2
]}

Ferrero, Enrico ^{[1
]}

Bornancin, Frederic ^{[1
]}

机构：

[1] Novartis Inst BioMed Res NIBR, Autoimmun Transplantat & Inflammat, Novartis Campus, Basel, Switzerland

[2] NIBR, Oncol, Novartis Campus, Basel, Switzerland

[3] NIBR, Chem Biol & Therapeut, Novartis Campus, Basel, Switzerland

[4] Novartis Pharma AG, BioMarker Dev, Novartis Campus, Basel, Switzerland

来源：

ONCOGENESIS | 2021年 / 10卷 / 04期

关键词：

NF-KAPPA-B; UBIQUITIN LIGASE; ACTIVATION; CARMA1; PHOSPHORYLATION; INHIBITOR; MECHANISM; LYMPHOMA; BCL10;

D O I：

10.1038/s41389-021-00321-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-kappa B activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in NF-kappa B regulation. In human lymphocytes, gain-of-function defects in this pathway lead to lymphoproliferative disorders. CARD10, the prototypical CARD-CC protein in non-hematopoietic cells, is overexpressed in several cancers and has been associated with poor prognosis. However, regulation of CARD10 remains poorly understood. Here, we identified CARD10 as the first MALT1 substrate in non-hematopoietic cells and showed that CARD10 cleavage by MALT1 at R587 dampens its capacity to activate NF-kappa B. Preventing CARD10 cleavage in the lung tumor A549 cell line increased basal levels of IL-6 and extracellular matrix components in vitro, and led to increased tumor growth in a mouse xenograft model, suggesting that CARD10 cleavage by MALT1 might be a built-in mechanism controlling tumorigenicity.

引用

页数：11

共 59 条

[1] MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes [J].

Baens, Mathijs ;

Bonsignore, Luca ;

Somers, Riet ;

Vanderheydt, Charlotte ;

Weeks, Stephen D. ;

Gunnarsson, Jenny ;

Nilsson, Ewa ;

Roth, Robert G. ;

Thome, Margot ;

Marynen, Peter .

PLOS ONE, 2014, 9 (08)

[2] The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition [J].

Bardet, Maureen ;

Unterreiner, Adeline ;

Malinverni, Claire ;

Lafossas, Frederique ;

Vedrine, Corinne ;

Boesch, Danielle ;

Kolb, Yeter ;

Kaiser, Daniel ;

Gluck, Anton ;

Schneider, Martin A. ;

Katopodis, Andreas ;

Renatus, Martin ;

Simic, Oliver ;

Schlapbach, Achim ;

Quancard, Jean ;

Regnier, Catherine H. ;

Bold, Guido ;

Pissot-Soldermann, Carole ;

Carballido, Jose M. ;

Kovarik, Jiri ;

Calzascia, Thomas ;

Bornancin, Frederic .

IMMUNOLOGY AND CELL BIOLOGY, 2018, 96 (01) :81-99

[3] CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-κB [J].

Bertin, J ;

Wang, L ;

Guo, Y ;

Jacobson, MD ;

Poyet, JL ;

Srinivasula, SM ;

Merriam, S ;

DiStefano, PS ;

Alnemri, ES .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (15) :11877-11882

[4] CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis [J].

Chang, Yi-Wen ;

Chiu, Ching-Feng ;

Lee, Kang-Yun ;

Hong, Chih-Chen ;

Wang, Yi-Yun ;

Cheng, Ching-Chia ;

Jan, Yi-Hua ;

Huang, Ming-Shyan ;

Hsiao, Michael ;

Ma, Jui-Ti ;

Su, Jen-Liang .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 192 (01) :64-75

[5] T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20 [J].

Coornaert, Beatrice ;

Baens, Mathijs ;

Heyninck, Karen ;

Bekaert, Tine ;

Haegman, Mira ;

Staal, Jens ;

Sun, Lijun ;

Chen, Zhijian J. ;

Marynen, Peter ;

Beyaert, Rudi .

NATURE IMMUNOLOGY, 2008, 9 (03) :263-271

[6] Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome [J].

David, Liron ;

Li, Yang ;

Ma, Jun ;

Garner, Ethan ;

Zhang, Xinzheng ;

Wu, Hao .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (07) :1499-1504

[7] CARMA3 is upregulated in human pancreatic carcinoma, and its depletion inhibits tumor proliferation, migration, and invasion [J].

Du, Shiyu ;

Jia, Liping ;

Zhang, Yanli ;

Fang, Long ;

Zhang, Xiang ;

Fan, Yanhua .

TUMOR BIOLOGY, 2014, 35 (06) :5965-5970

[8] The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer [J].

Ekambaram, Prasanna ;

Lee, Jia-Ying ;

Hubel, Nathaniel E. ;

Hu, Dong ;

Yerneni, Saigopalakrishna ;

Campbell, Phil G. ;

Pollock, Netanya ;

Klei, Linda R. ;

Concel, Vincent J. ;

Delekta, Phillip C. ;

Chinnaiyan, Arul M. ;

Tomlins, Scott A. ;

Rhodes, Daniel R. ;

Priedigkeit, Nolan ;

Lee, Adrian V. ;

Oesterreich, Steffi ;

McAllister-Lucas, Linda M. ;

Lucas, Peter C. .

CANCER RESEARCH, 2018, 78 (05) :1225-1240

[9] MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling [J].

Elton, Lynn ;

Carpentier, Isabelle ;

Staal, Jens ;

Driege, Yasmine ;

Haegman, Mira ;

Beyaert, Rudi .

FEBS JOURNAL, 2016, 283 (03) :403-412

[10] CARMA3 is overexpressed in human glioma and promotes cell invasion through MMP9 regulation in A172 cell line [J].

Feng, Xingjun ;

Miao, Guozhuan ;

Han, Yipeng ;

Xu, Yi .

TUMOR BIOLOGY, 2014, 35 (01) :149-154

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