Genetics and heritability of coronary artery disease and myocardial infarction

被引：108

作者：

Mayer, B. ^{[1
]}

Erdmann, J. ^{[1
]}

Schunkert, H. ^{[1
]}

机构：

[1] Univ Klinikum Schleswig Holstein, Med Klin 2, D-23538 Lubeck, Germany

来源：

CLINICAL RESEARCH IN CARDIOLOGY | 2007年 / 96卷 / 01期

关键词：

myocardial infarction; coronary artery disease; heritability; genetics;

D O I：

10.1007/s00392-006-0447-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A positive family history is frequently reported by patients with coronary artery disease (CAD) or myocardial infarction. For risk stratification, it is crucial to distinguish between accidental reoccurrence of sporadic cases and cases with a true heritable component of the conditions. A familial predisposition is assumed when a myocardial infarction is diagnosed by a male first degree relative before the 55th year of life or a female first degree relative before the 65th year of life. The current manuscript reviews major studies from which a familial risk of CAD or myocardial infarction can be inferred. Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction. © 2006 Steinkopff-Verlag.

引用

页码：1 / 7

页数：7

共 45 条

[1] Fifteen percent of myocardial infarctions and coronary revascularizations explained by family history unrelated to conventional risk factors - The Reykjavik Cohort Study [J].

Andresdottir, MB ;

Sigurdsson, G ;

Sigvaldason, H ;

Gudnason, V .

EUROPEAN HEART JOURNAL, 2002, 23 (21) :1655-1663

[2] Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the Prospective Cardiovascular Munster (PROCAM) study [J].

Assmann, G ;

Cullen, P ;

Schulte, H .

CIRCULATION, 2002, 105 (03) :310-315

[3] After myocardial infarction carvedilol improves insulin resistance compared to metoprolol [J].

Basat O. ;

Ucak S. ;

Seber S. ;

Oztekin E. ;

Altuntas Y. .

Clinical Research in Cardiology, 2006, 95 (2) :99-104

[4] Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status [J].

Beer, S ;

Reincke, M ;

Kral, M ;

Lie, SZ ;

Steinhauer, S ;

Schmidt, HHHW ;

Allolio, B ;

Neubauer, S .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2002, 40 (03) :420-428

[5]

BENNET AM, 2006, IN PRESS ATHEROSCLER

[6] Transcription factor MEF2A mutations in patients with coronary artery disease [J].

Bhagavatula, MRK ;

Fan, C ;

Shen, GQ ;

Cassano, J ;

Plow, EF ;

Topol, EJ ;

Wang, Q .

HUMAN MOLECULAR GENETICS, 2004, 13 (24) :3181-3188

[7] Inadequate medical treatment of patients with coronary artery disease by primary care physicians in Germany [J].

Bischoff, B. ;

Silber, S. ;

Richartz, B. M. ;

Pieper, L. ;

Klotsche, J. ;

Wittchen, H. -U. .

CLINICAL RESEARCH IN CARDIOLOGY, 2006, 95 (08) :405-412

[8] The joins impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality [J].

Boer, JMA ;

Feskens, EJM ;

Verschuren, WMM ;

Seidell, JC ;

Kromhout, D .

EPIDEMIOLOGY, 1999, 10 (06) :767-770

[9] A comprehensive linkage analysis for myocardial infarction and its related risk factors [J].

Broeckel, U ;

Hengstenberg, C ;

Mayer, B ;

Holmer, S ;

Martin, LJ ;

Comuzzie, AG ;

Blangero, J ;

Nürnberg, P ;

Reis, A ;

Riegger, GAJ ;

Jacob, HJ ;

Schunkert, H .

NATURE GENETICS, 2002, 30 (02) :210-214

[10] DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS A POTENT RISK FACTOR FOR MYOCARDIAL-INFARCTION [J].

CAMBIEN, F ;

POIRIER, O ;

LECERF, L ;

EVANS, A ;

CAMBOU, JP ;

ARVEILER, D ;

LUC, G ;

BARD, JM ;

BARA, L ;

RICARD, S ;

TIRET, L ;

AMOUYEL, P ;

ALHENCGELAS, F ;

SOUBRIER, F .

NATURE, 1992, 359 (6396) :641-644

← 1 2 3 4 5 →