Genomics of vancomycin-resistant Enterococcus faecium

被引：62

作者：

Gorrie, Claire ^{[1
]}

Higgs, Charlie ^{[1
]}

Carter, Glen ^{[1
]}

Stinear, Timothy P. ^{[2
,3
]}

Howden, Benjamin ^{[1
,3
,4
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Microbiol Diagnost Unit,Publ Hlth Lab, Melbourne, Vic, Australia

[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Doherty Appl Microbial Genom, Melbourne, Vic, Australia

[4] Austin Hlth, Dept Infect Dis, Heidelberg, Vic, Australia

来源：

MICROBIAL GENOMICS | 2019年 / 5卷 / 07期

基金：

英国医学研究理事会;

关键词：

Enterococcus faecium; antibiotic resistance; whole-genome sequencing; SEQUENCE TYPING SCHEME; GLYCOPEPTIDE RESISTANCE; GENE-CLUSTER; ANTIMICROBIAL RESISTANCE; LINEZOLID-RESISTANT; MOLECULAR CHARACTERIZATION; CORE GENOME; VANA; EMERGENCE; EVOLUTION;

D O I：

10.1099/mgen.0.000283

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vancomycin-resistant Enterococcus faecium (VREfm) is a globally significant public health threat and was listed on the World Health Organization's 2017 list of high-priority pathogens for which new treatments are urgently needed. Treatment options for invasive VREfm infections are very limited, and outcomes are often poor. Whole-genome sequencing is providing important new insights into VREfm evolution, drug resistance and hospital adaptation, and is increasingly being used to track VREfm transmission within hospitals to detect outbreaks and inform infection control practices. This mini-review provides an overview of recent data on the use of genomics to understand and respond to the global problem of VREfm.

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页数：8

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