Active or passive immunisation against cholecystokinin-33 stimulates growth of pigs

被引：0

作者：

Shu, D. M. ^{[2
]}

Qin, J. P. ^{[3
]}

Ma, X. Y. ^{[2
]}

Xue, C. Y. ^{[1
]}

Liu, J. Z. ^{[3
]}

Bi, Y. Z. ^{[3
]}

Cao, Y. C. ^{[1
]}

机构：

[1] Sun Yat Sen Univ, State Key Lab Biocontrol, Sch Life Sci, Guangzhou 510006, Peoples R China

[2] Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China

[3] S China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China

来源：

FOOD AND AGRICULTURAL IMMUNOLOGY | 2009年 / 20卷 / 04期

关键词：

CCK; appetite; feed intake; growth; immunisation; pig; FOOD-INTAKE; GASTROINTESTINAL HORMONES; ESCHERICHIA-COLI; PEPTIDE YY; APPETITE; GASTRIN; SWINE;

D O I：

10.1080/09540100903365845

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The purpose of this study was to determine the effect of active or passive immunisation against cholecystokinin (CCK) peptide on feed intake and body weight gain in pigs. For active immunisation, recombinant CCK-33 concatenate polypeptide was employed to immunise pigs, while passive immunisation was achieved by egg powders containing CCK-specific antibodies from laying hens that were immunised with recombinant CCK-33 peptide. Enzyme-linked immunosorbent assay showed that the active immunised pigs had significantly higher levels of CCK antibodies in serum than the control ones (p0.05). Actively or passively immunised pigs had significantly higher body weight, average daily gain and average daily feed intake than that of the control ones (p0.05). The results suggest that active or passive immunisation against CCK-33 peptide has stimulatory effects on growth of pigs. Thus, immunisation against CCK-33 may be used as an alternative way to enhance pig growth.

引用

页码：345 / 354

页数：10

共 30 条

[1] TROPHIC ACTION OF GASTROINTESTINAL HORMONES [J].

BARROWMAN, JA .

DIGESTION, 1975, 12 (02) :92-104

[2] Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production [J].

Colucci, R ;

Blandizzi, C ;

Tanini, M ;

Vassalle, C ;

Breschi, MC ;

Del Tacca, M .

BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (03) :338-348

[3]

ENOCHS MR, 1977, FED PROC, V36, P1942

[4]

FIGLEWICZ DP, 1987, ANNU REV PHYSIOL, V49, P383

[5] Growth hormone upregulates gastrin and peptide YY gene expression [J].

Gomez, G ;

Udupi, V ;

Qi, X ;

Lluis, F ;

Rajaraman, S ;

Thompson, JC ;

Greeley, GH .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (03) :E582-E586

[6] Hypothalamic control of energy balance [J].

Harrold, JA .

CURRENT DRUG TARGETS, 2004, 5 (03) :207-219

[7]

Kuntz Emmanuelle, 2004, JOP, V5, P464

[8] Field evaluation of chicken egg yolk immunoglobulins specific for bovine rotavirus in neonatal calves [J].

Kuroki, M ;

Ohta, M ;

Ikemori, Y ;

Icatlo, FC ;

Kobayashi, C ;

Yokoyama, H ;

Kodama, Y .

ARCHIVES OF VIROLOGY, 1997, 142 (04) :843-851

[9] Peptide YY, appetite and food intake [J].

le Roux, CW ;

Bloom, SR .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2005, 64 (02) :213-216

[10] Cholecystokinin cells [J].

Liddle, RA .

ANNUAL REVIEW OF PHYSIOLOGY, 1997, 59 :221-242

← 1 2 3 →