Concise Synthesis of PM-94128 and Y-05460M-A

被引：19

作者：

Enomoto, Masaru ^{[1
]}

Kuwahara, Shigefumi ^{[1
]}

机构：

[1] Tohoku Univ, Lab Appl Bioorgan Chem, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 19期

关键词：

BIOLOGICALLY-ACTIVE METABOLITES; MICROBIAL PRODUCTS; ISOCOUMARIN; DERIVATIVES;

D O I：

10.1021/jo9014968

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-L-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-BOC-L-valine by the same approach, which enabled its stereochemical determination.

引用

页码：7566 / 7569

页数：4

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