Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin

被引：99
作者：
Chen, Shuting [1 ]
Wu, Jie [2 ]
Tang, Qiang [1 ]
Xu, Chenlan [1 ]
Huang, Yan [1 ]
Huang, Da [1 ]
Luo, Fang [1 ]
Wu, Yuanzi [1 ]
Yan, Fen [1 ]
Weng, Zuquan [1 ]
Wang, Shaoyun [1 ]
机构：
[1] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China
[2] Fujian Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Fuzhou 350005, Fujian, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2020年 / 228卷
关键词：
Curcumin; Hydroxyethyl starch; Micellar nanoparticle; Stability; Antioxidant; Anticancer; PHYSICOCHEMICAL PROPERTIES; DELIVERY; NANOPARTICLES; BIOAVAILABILITY; PRODUCTS; ENHANCE; DISEASE;
D O I：
10.1016/j.carbpol.2019.115398
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study, amphiphilic conjugates were synthesized by conjugating curcumin (CUR) to a food-derived hydrophilic hydroxyethyl starch (HES) via an acid-labile ester linker. The self-assembly of the conjugates formed uniform micellar nanoparticles (HES-CUR NPs) with a desirable drug loading efficiency, excellent colloidal and storage stability, as well as acid-responsive release manner. Besides, the formation of the nanoparticles increased the solubility of CUR to thousands times higher than free CUR, and effectively protected the loaded CUR from degradation upon exposure to UV light and high temperature. In vitro cytotoxicity assay and radical scavenging experiments demonstrated that the HES-CUR NPs significantly improved the cytocompatibility, anticancer and antioxidant activity of CUR due to the enhanced solubility, stability, and bioavailability. The HES-CUR NPs reported herein have a great potential in developing functional food or pharmaceutical formulations for preventing or treating various diseases such as inflammatory diseases and cancer.
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页数：9
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