Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

被引：52

作者：

Bergmann, Clara ^{[1
]}

van Loon, Welmoed ^{[1
]}

Habarugira, Felix ^{[2
]}

Tacoli, Costanza ^{[1
]}

Jager, Julia C. ^{[1
]}

Savelsberg, Darius ^{[1
]}

Nshimiyimana, Fabian ^{[3
]}

Rwamugema, Elias ^{[2
]}

Mbarushimana, Djibril ^{[2
]}

Ndoli, Jules ^{[2
]}

Sendegeya, Augustin ^{[2
]}

Bayingana, Claude ^{[4
]}

Mockenhaupt, Frank P. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Berlin, Germany

[2] Univ Teaching Hosp Butare, Butare, Rwanda

[3] Kabutare Dist Hosp, Butare, Rwanda

[4] Univ Rwanda, Kigali, Rwanda

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 01期

关键词：

ARTEMISININ RESISTANCE;

D O I：

10.3201/eid2701.203527

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

引用

页码：294 / 296

页数：3

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