Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes

被引：8

作者：

Bashir, Qamar

Rashid, Naeem

Akhtar, Muhammad

机构：

[1] Univ Punjab, Sch Biol Sci, Lahore 54590, Pakistan

[2] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 48期

关键词：

D O I：

10.1039/b609925d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The condensation process catalysed by 2-amino-3-oxobutyrate CoA ligase (KBL; also known as 2-amino-3-ketobutyrate ligase) involves the loss of the pro-R hydrogen atom of glycine and occurs with the inversion of stereochemistry; a similar scenario is envisaged for the condensation step of other alpha-oxoamine synthases.

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页码：5065 / 5067

页数：3

相关论文

共 17 条

[1] BIOSYNTHESIS OF 5-AMINOLEVULINIC ACID - INVOLVEMENT OF A RETENTION-INVERSION MECHANISM [J].

ABBOUD, MM ;

JORDAN, PM ;

AKHTAR, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1974, (16) :643-644

[2] MECHANISM OF ACTION OF DELTA-AMINOLAEVULATE SYNTHETASE AND SYNTHESIS OF STEREOSPECIFICALLY TRITIATED GLYCINE [J].

AKHTAR, M ;

JORDAN, PM .

CHEMICAL COMMUNICATIONS, 1968, (24) :1691-&

[3] MECHANISM AND STEREOCHEMISTRY OF ENZYMIC REACTIONS INVOLVED IN PORPHYRIN BIOSYNTHESIS [J].

AKHTAR, M ;

ABBOUD, MM ;

BARNARD, G ;

JORDAN, P ;

ZAMAN, Z .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1976, 273 (924) :117-136

[4] The crystal structure of 8-amino-7-oxononanoate synthase: A bacterial PLP-dependent, acyl-CoA-condensing enzyme [J].

Alexeev, D ;

Alexeeva, M ;

Baxter, RL ;

Campopiano, DJ ;

Webster, SP ;

Sawyer, L .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 284 (02) :401-419

[5]

BATTERSBY R, 1975, PORPHYRINS METALLOPO, P61

[6] FORMATION OF GLYCINE AND AMINOACETONE FROM L-THREONINE BY RAT-LIVER MITOCHONDRIA [J].

BIRD, MI ;

NUNN, PB ;

LORD, LAJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 802 (02) :229-236

[7] CATABOLISM OF THREONINE IN MAMMALS BY COUPLING OF L-THREONINE 3-DEHYDROGENASE WITH 2-AMINO-3-OXOBUTYRATE-COA LIGASE [J].

DALE, RA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 544 (03) :496-503

[8]

Jordan P.M., 1991, BIOSYNTHESIS TETRAPY, V19, P1, DOI DOI 10.1016/30167-7306(08)60108-8

[9] MECHANISM OF ACTION OF SERINE TRANSHYDROXYMETHYLASE [J].

JORDAN, PM ;

AKHTAR, M .

BIOCHEMICAL JOURNAL, 1970, 116 (02) :277-&

[10] THREONINE DEGRADATION BY SERRATIA-MARCESCENS [J].

KOMATSUBARA, S ;

MURATA, K ;

KISUMI, M ;

CHIBATA, I .

JOURNAL OF BACTERIOLOGY, 1978, 135 (02) :318-323