A practical preparation of 5-(ketoaryl)thiazoles

被引：35

作者：

Marcantonio, KM ^{[1
]}

Frey, LF ^{[1
]}

Murry, JA ^{[1
]}

Chen, CY ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(02)02230-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article describes a facile synthesis of 2-substituted-5-(ketoaryl)thiazoles, which are important intermediates for the synthesis of biologically active compounds. A variety of 2-substituted thiazole anions were added to aryl nitriles to provide the desired ketones after aqueous hydrolysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8845 / 8848

页数：4

共 10 条

[1] SYNTHESIS OF (TRIMETHYLSILYL)THIAZOLES AND REACTIONS WITH CARBONYL-COMPOUNDS - SELECTIVITY ASPECTS AND SYNTHETIC UTILITY [J].

DONDONI, A ;

FANTIN, G ;

FOGAGNOLO, M ;

MEDICI, A ;

PEDRINI, P .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (08) :1748-1761

[2] PREPARATION AND UTILITY OF DIANIONS FROM N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE [J].

GRAHAM, SL ;

SCHOLZ, TH .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (13) :4260-4263

[3]

Hantzsch A., 1888, BER DTSCH CHEM GES, V21, P938

[4]

KNOLL A, 1985, J PRAKT CHEM, V3, P463

[5] SYNTHESIS OF SUBSTITUTED 2-AMINOTHIAZOLES [J].

LIN, Y ;

SEIFERT, CM ;

KANG, SM ;

DUSZA, JP ;

LANG, SA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (07) :1377-1383

[6]

Pyne SG, 1998, SYNLETT, P280

[7]

RAJAPPA S, 1982, P INDIAN AS-CHEM SCI, V91, P445

[8] Synthesis of 4-substituted 2-phenylaminothiazoles from amidines.: A convenient route to 4-trichloromethylthiazoles [J].

Romero-Ortega, M ;

Aviles, A ;

Cruz, R ;

Fuentes, A ;

Gómez, RM ;

Plata, A .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (21) :7244-7247

[9] AN EASY GENERAL-SYNTHESIS OF 2-(N,N-DIALKYLAMINO)THIAZOL-5-YL ALDEHYDES AND KETONES [J].

SAWHNEY, I ;

WILSON, JRH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (02) :329-331

[10] REACTIONS OF A 4-(TRIFLUOROMETHYL)THIAZOLE DIANION [J].

SOUTH, MS ;

VANSANT, KA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (04) :1017-1024

← 1 →