The Use of Selective Serotonin Reuptake Inhibitors in Elderly Patients

被引：12

作者：

Chemali, Zeina ^{[1
,4
]}

Chahine, Lama M. ^{[2
]}

Fricchione, Gregory ^{[1
,3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[2] Cleveland Clin, Cleveland, OH 44106 USA

[3] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[4] Brigham & Womens Hosp, Div Cognit & Behav Neurol, Boston, MA 02115 USA

来源：

HARVARD REVIEW OF PSYCHIATRY | 2009年 / 17卷 / 04期

关键词：

geriatrics; selective serotonin reuptake inhibitors; LATE-LIFE DEPRESSION; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; PRIMARY-CARE PATIENTS; DRUG-INTERACTIONS; MAJOR DEPRESSION; FRONTOTEMPORAL DEMENTIA; DOUBLE-BLIND; ANTIDEPRESSANT THERAPY; PARKINSONS-DISEASE;

D O I：

10.1080/10673220903129798

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Depression is common among the elderly, and several factors need to be taken into account in selecting the appropriate antidepressant in this age group. Various physiologic changes occur in individuals as they age, potentially leading to changes in the pharmacodynamic and pharmacokinetic properties of drugs in elderly individuals. The efficacy of various medications, their side-effect profiles, and the potential for drug-drug interactions may differ in older patients compared to younger ones. The selective serotonin reuptake inhibitors (SSRIs), which are seen as being among the first-line agents for treatment of depression in elderly patients, have been shown to be effective but carry with them side effects and drug-drug interactions that warrant special attention when these medications are prescribed to older individuals. This review focuses on the pharmacology of SSRIs in elderly patients and on practical issues related to using these medications.

引用

页码：242 / 253

页数：12

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