Pathogenesis of psoriasis in the "omic" era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis

被引：6

作者：

Szczerkowska-Dobosz, Aneta ^{[1
]}

Krasowska, Dorota ^{[2
]}

Bartosinska, Joanna ^{[2
]}

Stawczyk-Macieja, Marta ^{[1
]}

Walczak, Aleksandra ^{[2
]}

Owczarczyk-Saczonek, Agnieszka ^{[3
]}

Reich, Adam ^{[4
]}

Batycka-Baran, Aleksandra ^{[5
]}

Czajkowski, Rafal ^{[6
]}

Dobrucki, Iwona T. ^{[7
]}

Dobrucki, Lawrence W. ^{[7
,8
,9
]}

Gorecka-Sokolowska, Magdalena ^{[10
]}

Janaszak-Jasiecka, Anna ^{[8
,9
]}

Kalinowski, Leszek ^{[7
,8
,9
]}

Nowicki, Roman J. ^{[1
]}

Ploska, Agata ^{[8
,9
]}

Purzycka-Bohdan, Dorota ^{[1
]}

Radulska, Adrianna ^{[8
,9
]}

Reszka, Edyta ^{[11
]}

Samotij, Dominik ^{[4
]}

Siekierzycka, Anna ^{[8
,9
]}

Slominski, Andrzej T. ^{[12
,13
,14
]}

Slominski, Radomir M. ^{[15
]}

Sobalska-Kwapis, Marta ^{[16
]}

Strapagiel, Dominik ^{[10
]}

Szczech, Justyna ^{[4
]}

Zmijewski, Michal A. ^{[17
]}

Nedoszytko, Boguslaw ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Dermatol Venereol & Allergol, 7 Debinki St, PL-80211 Gdansk, Poland

[2] Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, Lublin, Poland

[3] Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland

[4] Univ Rzeszow, Dept Dermatol, Rzeszow, Poland

[5] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[6] Jurasz Univ Hosp 1, Dept Dermatol Sexually Transmitted Disorders & Im, Bydgoszcz, Poland

[7] Beckman Inst Adv Sci & Technol, Urbana, IL USA

[8] Univ Illinois, Dept Bioengn, Urbana, IL USA

[9] Med Univ Gdansk, Dept Med Lab Diagnost, Gdansk, Poland

[10] Biobanking & Biomol Resources Res Infrastruct BBM, Gdansk, Poland

[11] Nofer Inst Occupat Med, Dept Mol Genet & Epigenet, Lodz, Poland

[12] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL 35294 USA

[13] Univ Alabama Birmingham, Comprehens Canc Ctr, Canc Chemoprevent Program, Birmingham, AL USA

[14] VA Med Ctr, Pathol & Lab Med, Birmingham, AL USA

[15] Univ Alabama Birmingham, Dept Med & Microbiol, Div Clin Immunol & Rheumatol, Birmingham, AL USA

[16] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biophys, Biobank Lab, Lodz, Poland

[17] Med Univ Gdansk, Dept Histol, Gdansk, Poland

来源：

POSTEPY DERMATOLOGII I ALERGOLOGII | 2020年 / 37卷 / 05期

关键词：

psoriatic arthritis; genetics; immunopathogenesis; classification; treatment; JOINT DISEASE; PREVALENCE; SUSCEPTIBILITY; MANAGEMENT; CELLS; RISK; SPONDYLOARTHROPATHIES; ASSOCIATION; DACTYLITIS; CRITERIA;

D O I：

10.5114/ada.2020.100478

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.

引用

页码：625 / 634

页数：10

共 2 条

[1] Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
Owczarczyk-Saczonek, Agnieszka
Purzycka-Bohdan, Dorota
Nedoszytko, Boguslaw
Reich, Adam
Szczerkowska-Dobosz, Aneta
Bartosinska, Joanna
Batycka-Baran, Aleksandra
Czajkowski, Rafat
Dobrucki, Iwona T.
Dobrucki, Lawrence W.
Gorecka-Sokolowska, Magdalena
Janaszak-Jasiecka, Anna
Kalinowski, Leszek
Krasowska, Dorota
Radulska, Adrianna
Reszka, Edyta
Samotij, Dominik
Slominski, Andrzej
Slominski, Radomir
Sobalska-Kwapis, Marta
Stawczyk-Macieja, Marta
Strapagiel, Dominik
Szczech, Justyna
Zmijewski, Michal
Nowicki, Roman J.
POSTEPY DERMATOLOGII I ALERGOLOGII, 2020, 37 (04): : 452 - 467
[2] Epidemiology, genetics and management of psoriatic arthritis 2013: focus on developments of who develops the disease, its clinical features, and emerging treatment options
Haroon, Muhammad
FitzGerald, Oliver
Winchester, Robert
PSORIASIS-TARGETS AND THERAPY, 2013, 3 : 11 - 23

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