Abuse liability of medications used to treat attention-deficit/hyperactivity disorder (ADHD)

被引:42
作者
Kollins, Scott H. [1 ]
机构
[1] Duke Univ, ADHD Program, Dept Psychiat & Behav Sci, Sch Med, Durham, NC 27705 USA
关键词
D O I
10.1080/10550490601082775
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The use of psychostimulants to treat attention-deficit/ hyperactivity disorder (ADHD) has been controversial for a number of reasons. In an effort to clarify the extent to which the psychostimulant methylphenidate has abuse potential, the existing published evidence has been reviewed and is summarized here, with an emphasis on delineating a number of related but independent issues that are often confused. The existing evidence reviewed is pertinent to three questions: Does stimulant drug use increase the risk for substance abuse later in life? Do ADHD medications have the potential for abuse?, and What is the distinction between drug abuse and misuse/diversion with respect to ADHD medication?.
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收藏
页码:35 / 44
页数:10
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共 58 条
[1]   Altered responsiveness to cocaine in rats exposed to methylphenidate during development [J].
Andersen, SL ;
Arvanitogiannis, A ;
Pliakas, AM ;
LeBlanc, C ;
Carlezon, WA .
NATURE NEUROSCIENCE, 2002, 5 (01) :13-14
[2]   Guidelines and methodological reviews concerning drug abuse liability assessment [J].
Balster, RL ;
Bigelow, GE .
DRUG AND ALCOHOL DEPENDENCE, 2003, 70 (03) :S13-S40
[3]  
BERGMAN J, 1989, J PHARMACOL EXP THER, V251, P150
[4]   Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study [J].
Biederman, J ;
Wilens, T ;
Mick, E ;
Faraone, SV ;
Weber, W ;
Curtis, S ;
Thornell, A ;
Pfister, K ;
Jetton, JG ;
Soriano, J .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (01) :21-29
[5]   Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder [J].
Biederman, J ;
Wilens, T ;
Mick, E ;
Spencer, T ;
Faraone, SV .
PEDIATRICS, 1999, 104 (02) :art. no.-e20
[6]   STIMULUS FUNCTIONS OF DRUGS AND THE ASSESSMENT OF ABUSE LIABILITY [J].
BRADY, JV ;
HIENZ, RD ;
ATOR, NA .
DRUG DEVELOPMENT RESEARCH, 1990, 20 (02) :231-249
[7]  
BRADY JV, 1984, NATL I DRUG ABUSE MO, V52
[8]   Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons [J].
Brandon, CL ;
Marinelli, M ;
White, FJ .
BIOLOGICAL PSYCHIATRY, 2003, 54 (12) :1338-1344
[9]   Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats [J].
Brandon, CL ;
Marinelli, M ;
Baker, LK ;
White, FJ .
NEUROPSYCHOPHARMACOLOGY, 2001, 25 (05) :651-661
[10]   Enduring behavioral effects of early exposure to methylphenidate in rats [J].
Carlezon, WA ;
Mague, SD ;
Andersen, SL .
BIOLOGICAL PSYCHIATRY, 2003, 54 (12) :1330-1337