β-lactamase inhibitors

被引：64

作者：

Page, MGF ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Preclin Res, Div Pharma, CH-4070 Basel, Switzerland

来源：

DRUG RESISTANCE UPDATES | 2000年 / 3卷 / 02期

关键词：

beta-lactamase; beta-lactamase inhibitor; resistance;

D O I：

10.1054/drup.2000.0137

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of beta-lactamase inhibitors in combination with a beta-lactamase-susceptible antibiotic is a useful strategy to rescue otherwise good antibiotics from failure. However, recent years have seen a rise in the numbers of beta-lactamases that are insensitive to the available beta-lactamase inhibitors. This review summarizes of the mechanisms of action of the principal types of inhibitors and the ways in which beta-lactamase are thought to develop resistance towards them. Ten general classes of inhibitors are reviewed, especially those of therapeutic importance (clavulanic acid, penam sulfones and carbapenems). (C) 2000 Harcourt Publishers Ltd.

引用

页码：109 / 125

页数：17

共 110 条

[1]

[Anonymous], CHEM BETA LACTAMS

[2] 6-ACETYLMETHYLENEPENICILLANIC ACID (RO 15-1903), A POTENT BETA-LACTAMASE INHIBITOR .1. INHIBITION OF CHROMOSOMALLY AND R-FACTOR-MEDIATED BETA-LACTAMASES [J].

ARISAWA, M ;

THEN, RL .

JOURNAL OF ANTIBIOTICS, 1982, 35 (11) :1578-1583

[3] COMPARATIVE ACTIVITIES OF THE BETA-LACTAMASE INHIBITORS YTR-830, SODIUM CLAVULANATE, AND SULBACTAM COMBINED WITH AMOXICILLIN OR AMPICILLIN [J].

ARONOFF, SC ;

JACOBS, MR ;

JOHENNING, S ;

YAMABE, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 26 (04) :580-582

[4] DIRECT OBSERVATION OF A TETRAHEDRAL BORONIC ACID BETA-LACTAMASE COMPLEX USING B-11 NMR-SPECTROSCOPY [J].

BALDWIN, JE ;

CLARIDGE, TDW ;

DEROME, AE ;

SMITH, BD ;

TWYMAN, M ;

WALEY, SG .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (08) :573-574

[5]

BATESON JH, 1997, Patent No. 10225

[6] THE INHIBITION OF CLASS-C BETA-LACTAMASES BY BORONIC ACIDS [J].

BEESLEY, T ;

GASCOYNE, N ;

KNOTTHUNZIKER, V ;

PETURSSON, S ;

WALEY, SG ;

JAURIN, B ;

GRUNDSTROM, T .

BIOCHEMICAL JOURNAL, 1983, 209 (01) :229-233

[7] BETA-LACTAMASE MUTATIONS FAR FROM THE ACTIVE-SITE INFLUENCE INHIBITOR BINDING [J].

BONOMO, RA ;

DAWES, CG ;

KNOX, JR ;

SHLAES, DM .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1995, 1247 (01) :121-125

[8] OHIO-1 BETA-LACTAMASE RESISTANT TO MECHANISM-BASED INACTIVATORS [J].

BONOMO, RA ;

CURRIEMCCUMBER, C ;

SHLAES, DM .

FEMS MICROBIOLOGY LETTERS, 1992, 92 (01) :79-82

[9] COMPLEMENTARY ROLES OF MUTATIONS AT POSITION-69 AND POSITION-242 IN A CLASS-A BETA-LACTAMASE [J].

BONOMO, RA ;

DAWES, CG ;

KNOX, JR ;

SHLAES, DM .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1995, 1247 (01) :113-120

[10] PENICILLANIC ACID SULFONE - AN UNEXPECTED ISOTOPE EFFECT IN THE INTERACTION OF 6-ALPHA-MONODEUTERIO AND 6-BETA-MONODEUTERIO AND OF 6,6-DIDEUTERIO DERIVATIVES WITH RTEM BETA-LACTAMASE FROM ESCHERICHIA-COLI [J].

BRENNER, DG ;

KNOWLES, JR .

BIOCHEMISTRY, 1981, 20 (13) :3680-3686

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