AGE and their receptor RAGE in systemic autoimmune diseases: An inflammation propagating factor contributing to accelerated atherosclerosis

被引：48
作者：
Nienhuis, Hans L. A. [1 ]
Westra, Johanna [1 ]
Smit, Andries J. [2 ]
Limburg, Pieter C. [1 ]
Kallenberg, Cees G. M. [1 ]
Bijl, Marc [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Div Clin Immunol & Rheumatol, Dept Internal Med, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Div Vasc Dis, Dept Internal Med, NL-9713 GZ Groningen, Netherlands
来源：
AUTOIMMUNITY | 2009年 / 42卷 / 04期
关键词：
AGE; RAGE; inflammation; atherosclerosis; systemic autoimmune diseases; GLYCATION END-PRODUCTS; VASCULAR ENDOTHELIAL-CELLS; SOLUBLE RECEPTOR; PLASMA-LEVELS; SERUM-LEVELS; ENDPRODUCTS; ACTIVATE; SRAGE; PROTEINS; FORM;
D O I：
10.1080/08916930902831746
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Systemic autoimmune diseases are associated with inflammation, and oxidative stress favouring the formation of advanced glycation endproducts (AGE), able to modulate cellular functions by activation of receptor for advanced glycation endproducts (RAGE). As RAGE expression is increased in an inflammatory milieu, present in patients with systemic autoimmune diseases, these patients are especially prone for the deleterious effects of AGE. Interaction of AGE with RAGE leads to intracellular signalling, and subsequent expression of adhesion molecules, chemokines, pro-inflammatory cytokines and up-regulation of RAGE itself. The AGE-RAGE interaction might act as a pro-inflammatory loop in these patients, contributing to chronic low grade inflammation rendering these individuals susceptible for development of accelerated atherosclerosis.
引用
收藏
页码：302 / 304
页数：3
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