Synthesis of RGD containing peptides and their bioactivities

被引：5

作者：

Zhao, M

Wang, C

Jiang, XR

Peng, SQ ^{[1
]}

机构：

[1] Peking Univ, Coll Pharmaceut Chem, Beijing 100083, Peoples R China

[2] Capital Pedag Univ, Beijing 100037, Peoples R China

来源：

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | 2002年 / 32卷 / 04期

关键词：

D O I：

10.1081/PB-120015464

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

RGDS, RGDV, and RGDF were used for the structural modification of YIGSR and YIGSK, the sequences involved in the development of metastasis disease. By use of a solution method, YIGSRRGDS, YIGSRRGDV, YIGSRRGDF, YIGSKRGDS, YIGSKRGDV, YIGSKRGDF, YIGSRYIGSK, and YIGSKYIGSR were prepared in good yield. The results of bioassay in vitro indicated that the target property of RGDS, RGDV, and RGDF to high affinity-receptors may be responsible for the enhanced anti-aggregation, anti-adhesion, and anti-invasion potency.

引用

页码：363 / 380

页数：18

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