Tissue-resident lymphocytes: sentinel of the transformed tissue

被引：6

作者：

Dadi, Saida ^{[1
]}

Li, Ming O. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Immunol, 1275 York Ave, New York, NY 10065 USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2017年 / 5卷

关键词：

Cancer immunosurveillance; Innate lymphoid cells; Innate-like T cells; INNATE LYMPHOID-CELLS; NK CELLS; T-CELLS; DIFFERENTIATION; NFIL3;

D O I：

10.1186/s40425-017-0244-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) alpha beta and TCR gamma delta lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy.

引用

页数：3

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