Current status and future prospects for anti-angiogenic therapies in cancer

被引：20
作者：
Staton, Carolyn A. [1 ]
Brown, Nicola J. [1 ]
Reed, Malcolm W. R. [1 ]
机构：
[1] Univ Sheffield, Sch Med & Biomed Sci, Microcirculat Res Grp, Acad Unit Surg Oncol, Sheffield S10 2RX, S Yorkshire, England
来源：
EXPERT OPINION ON DRUG DISCOVERY | 2009年 / 4卷 / 09期
关键词：
anti-angiogenic agents; bevacizumab; cancer; cetuximab; clinical trials; erlotinib; sunitinib; VEGF; ENDOTHELIAL GROWTH-FACTOR; PHASE-III TRIAL; RECOMBINANT HUMAN ENDOSTATIN; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; REFRACTORY COLORECTAL-CANCER; COOPERATIVE-ONCOLOGY-GROUP; TYROSINE KINASE INHIBITOR; BLOOD-VESSEL FORMATION; HUMAN PROSTATE-CANCER; SMOOTH-MUSCLE-CELLS;
D O I：
10.1517/17460440903196737
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Angiogenesis is essential for turnout growth and development and since the pioneering work of Judah Folkman several anti-angiogenic strategies have now been successfully employed. Objective: This article aims to present a detailed review of current knowledge of the main pathways involved in angiogenesis, the strategies employed for inhibition and the current status of angiogenesis inhibitors in therapeutic use. Methods: A systematic review of the literature was undertaken including angiogenesis in cancer and angiogenesis inhibitors in pre-clinical and clinical trials. Conclusion: While angiogenic inhibitors are now in clinical use, their limited benefits mean we must urgently develop strategies to improve the efficacy of this approach.
引用
收藏
页码：961 / 979
页数：19
相关论文
共 194 条
[1]   Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors [J].
Adams, Val R. ;
Leggas, Markos .
CLINICAL THERAPEUTICS, 2007, 29 (07) :1338-1353
[2]   VASCULAR REACTIONS OF NORMAL AND MALIGNANT TISSUES INVIVO .1. VASCULAR REACTIONS OF MICE TO WOUNDS AND TO NORMAL AND NEOPLASTIC TRANSPLANTS [J].
ALGIRE, GH ;
CHALKLEY, HW .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1945, 6 (01) :73-85
[3]  
[Anonymous], OXFORD TXB ONCOLOGY
[4]  
[Anonymous], 2008, ORGANOGENESIS
[5]  
ANTOINE N, 1994, CANCER RES, V54, P2073
[6]   Endothelial/pericyte interactions [J].
Armulik, A ;
Abramsson, A ;
Betsholtz, C .
CIRCULATION RESEARCH, 2005, 97 (06) :512-523
[7]  
Arteaga CL, 2001, J CLIN ONCOL, V19, p32S
[8]   Angiopoietins in malignancy [J].
Bach, F. ;
Uddin, F. J. ;
Burke, D. .
EJSO, 2007, 33 (01) :7-15
[9]  
Bachelder RE, 2001, CANCER RES, V61, P5736
[10]   Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling [J].
Baffert, F ;
Le, T ;
Sennino, B ;
Thurston, G ;
Kuo, CJ ;
Hu-Lowe, D ;
McDonald, DM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 290 (02) :H547-H559
12345678910