A case of Mikulicz's disease with Th2-biased cytokine profile: possible feature discriminable from Sjogren's syndrome

被引：28

作者：

Kudo-Tanaka, Eriko ^{[1
]}

Nakatsuka, Shinichi ^{[2
]}

Hirano, Toru ^{[3
]}

Kawai, Mari ^{[3
]}

Katada, Yoshinori ^{[4
]}

Matsushita, Masato ^{[1
]}

Ohshima, Shiro ^{[1
,5
]}

Ishii, Masaru ^{[1
]}

Miyatake, Kunio

Tanaka, Toshio ^{[3
]}

Saeki, Yukihiko ^{[1
,5
]}

机构：

[1] NHO Osaka Minami Med Ctr, Dept Rheumatol, Osaka 5868521, Japan

[2] NHO Osaka Minami Med Ctr, Dept Pathol, Osaka 5868521, Japan

[3] Osaka Univ, Grad Sch Med, Dept Resp Med Allergy & Rheumat Dis, Osaka, Japan

[4] NHO Osaka Minami Med Ctr, Dept Allergy, Osaka 5868521, Japan

[5] NHO Osaka Minami Med Ctr, Dept Clin Res, Osaka 5868521, Japan

来源：

MODERN RHEUMATOLOGY | 2009年 / 19卷 / 06期

关键词：

Mikulicz's disease; Immunoglobulin G4 (IgG4); CD40; ligation; Th2; Sjogren's syndrome; CELLS; IGG4; EXPRESSION; IGE; CD40;

D O I：

10.1007/s10165-009-0214-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article concerns a male patient with Mikulicz's disease (MD) accompanied with marked elevation of serum immunoglobulin (Ig)G4 and IgE levels. His peripheral blood mononuclear cells (PBMC) showed markedly enhanced in vitro production of interleukin (IL)-4, IL-5, IL-13, but not interferon gamma (IFN-gamma) compared with patients with Sjogren's syndrome (SS) and healthy donors, suggesting distinct Th2 bias in this MD patient. Besides the prominent infiltration of IgG4-producing plasma cells, the enhanced expression of both CD40 and CD40 ligand (CD40L) were observed in the swollen salivary gland of the MD patient, suggesting enhanced signaling pathways for the induction of IgG4 and IgE switching. Possible differences between MD and SS in light of their underlying pathogenesis are discussed.

引用

页码：691 / 695

页数：5

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