Investigation of Mg, K, Cu, Zn doped S53P4 bioactive glass in vitro studies; bioactivity and biodegradability features

In this study, it was aimed to produce by melt-quenching method non-additive (SiO2-Na2O-P2O5-CaO) and ion additive (SiO2-Na2O-P2O5-CaO-MgO-ZnO-K2O-CuO) bioactive glasses (different forms; powder and granule). In vitro bioactivity and biodegradability properties of bioactive glasses in different forms (granule and powder) were examined with Simulated Body Fluid (SBF) and Tris-HCI analyses. Chemical bonds structures and surface morphology analysis of bioactive glasses (both additive and non-additive) were performed with FT-IR and SEM-EDS analysis before and after SBF immersion. SBF studies showed that both S53P4 bioactive glasses had similar bioactivity. As a results of Tris-HCI studies, in vitro biodegradability of bioactive glasses in powder forms are better than bioactive glasses in granule forms because of rapid raise of its pH value in Tris-HCI. However, ion additive S53P4 powder bioactive glass had more stable degradation behavior in comparison with non-additive S53P4 powder bioactive glass.