Bromomaleimides: new reagents for the selective and reversible modification of cysteine

被引：79

作者：

Tedaldi, Lauren M. ^{[1
]}

Smith, Mark E. B. ^{[1
]}

Nathani, Ramiz I. ^{[1
]}

Baker, James R. ^{[1
]}

机构：

[1] UCL, Dept Chem, London, England

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 43期

关键词：

DEHYDROALANINE-CONTAINING PEPTIDES; SULFHYDRYL GROUPS; N-ETHYLMALEIMIDE; REACTIVITY; PROTEINS; CONJUGATION;

D O I：

10.1039/b915136b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.

引用

页码：6583 / 6585

页数：3

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