Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

被引：40

作者：

Chen, Jih-Jung ^{[1
]}

Tsai, Cheng-Shuan ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Shieh, Po-Chuen ^{[1
]}

Chen, Jinn-Fen ^{[3
]}

Sung, Ping-Jyun ^{[4
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Taitung Dist Agr Res & Extens Stn, Taitung 950, Taiwan

[4] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

来源：

FOOD CHEMISTRY | 2010年 / 119卷 / 03期

关键词：

Curcuma longa; Zingiberaceae; Structure elucidation; Sesquiterpenes; Inhibitory activity on neutrophil proinflammatory responses; BISABOLANE SESQUITERPENOIDS; ZEDOARIA; ANION;

D O I：

10.1016/j.foodchem.2009.07.060

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6 alpha-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16 and 23 exhibited inhibition (IC(50) <= 18.22 mu M) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 1216, and 23 inhibited fMLP/CB-induced elastase release with IC(50) values <= 14.28 mu M. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：974 / 980

页数：7

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