Distinctive properties of metastasis-initiating cells

被引:246
作者
Celia-Terrassa, Toni [1 ]
Kang, Yibin [1 ]
机构
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
基金
美国国家卫生研究院;
关键词
cancer metastasis; plasticity; epithelial-mesenchymal transition; metastasis-initiating cells; metastatic niche; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; MAMMARY STEM-CELLS; TUMOR PROGRESSION; BONE-MARROW; MICROENVIRONMENTAL REGULATION; BIOLOGICAL INSIGHTS; DISTANT METASTASIS; PROGENITOR CELLS; CARCINOMA-CELLS;
D O I
10.1101/gad.277681.116
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique population of metastasis-initiating cells (MICs). MICs possess advantageous traits that may originate in the primary tumor but continue to evolve during dissemination and colonization, including cellular plasticity, metabolic reprogramming, the ability to enter and exit dormancy, resistance to apoptosis, immune evasion, and co-option of other tumor and stromal cells. Better understanding of the molecular and cellular hallmarks of MICs will facilitate the development and deployment of novel therapeutic strategies.
引用
收藏
页码:892 / 908
页数:17
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