Omental milky spots - highly efficient "natural filter" for screening gastric cancer stem cells

被引：8

作者：

Cao, Liang ^{[1
]}

Hu, Xiang ^{[1
]}

Zhang, Yi ^{[2
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian 116011, Peoples R China

[2] Dalian Med Univ, Plast & Cosmet Med Coll, Dalian 116044, Peoples R China

来源：

MEDICAL HYPOTHESES | 2009年 / 73卷 / 06期

关键词：

D O I：

10.1016/j.mehy.2009.03.055

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Over the last decades, cancer stem cells (CSCs) have been identified in different solid tumors and three strategies have been employed to identify them as follows: (1) expression of cell surface markers, (2) ability to exclude fluorescent dye Hoescht 33342 in a cell population termed "side population" (SP), and (3) formation of tumorspheres in suspension culture. But these methods focus on a minor subset of tumor cells, initial CSCs are still hidden among them and genuine CSCs have not yet been isolated and purified. Here we propose a new strategy to identify and isolate gastric cancer stem cells - using omental milky spots to screen gastric cancer stem cells in peritoneal metastasis mouse models of gastric cancer. This strategy directly target cancer stem cells--which can cause a new tumor by itself. Omental milky spots and their macrophages become a highly efficient "natural filter" for screening gastric cancer stem cells. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1017 / 1018

页数：2

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