Optimal Duration of Continuous Video-Electroencephalography in Term Infants With Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia

被引：14

作者：

Mahfooz, Naeem ^{[1
,2
]}

Weinstock, Arie ^{[1
]}

Afzal, Bushra ^{[3
]}

Noor, Mariam ^{[1
]}

Lowy, David Vargas ^{[3
]}

Farooq, Osman ^{[1
]}

Finnegan, Sarah G. ^{[1
]}

Lakshminrusimha, Satyan ^{[3
]}

机构：

[1] SUNY Buffalo, Women & Childrens Hosp New York, Div Pediat Neurol, Dept Neurol, Buffalo, NY 14260 USA

[2] Epilepsy Ctr, Neurol Inst, 9500 Euclid Ave S51, Cleveland, OH 44195 USA

[3] SUNY Buffalo, Women & Childrens Hosp New York, Div Neonatol, Dept Pediat, Buffalo, NY USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2017年 / 32卷 / 06期

关键词：

cooling; electroencephalography; hypoxic ischemic encephalopathy; whole body hypothermia; seizures; background suppression; WHOLE-BODY HYPOTHERMIA; NEONATAL SEIZURES; ASPHYXIATED NEWBORNS; PERINATAL ASPHYXIA; PROGNOSTIC VALUE; EEG; TRIAL;

D O I：

10.1177/0883073816689325

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Continuous video-electroencephalography (EEG) is an important diagnostic and prognostic tool in newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. The optimal duration of continuous video-EEG during whole-body hypothermia is not known. We conducted a retrospective study of 35 neonates with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with continuous video-EEG. EEG ictal changes were detected in 9/35 infants (26%). Of these 9 infants, the seizures were initially observed within 30 minutes of EEG monitoring in 6 (67%), within 24 hours in 2 (22%), and during rewarming in 1 infant (11%). No new seizures were detected between 24-72 hours of therapeutic hypothermia. Background suppression was detected in 14 infants (40%) by 24 hours. In neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia, continuous video-EEG has the highest diagnostic yield within the first 24 hours and during the rewarming phase. In the absence of prior seizures or antiepileptic therapy, limiting continuous video-EEG to these periods in resource-limited settings may reduce cost during therapeutic hypothermia.

引用

页码：522 / 527

页数：6

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