GLUT-1 expression and response to chemoradiotherapy in rectal cancer

被引：36

作者：

Brophy, Sarah ^{[1
,3
]}

Sheehan, Katherine M. ^{[2
,3
]}

McNamara, Deborah A. ^{[1
,3
]}

Deasy, Joseph ^{[1
,3
]}

Bouchier-Hayes, David J. ^{[1
,3
]}

Kay, Elaine W. ^{[2
,3
]}

机构：

[1] Beaumont Hosp, Dept Surg, Dublin 9, Ireland

[2] Beaumont Hosp, Dept Pathol, Dublin 9, Ireland

[3] Royal Coll Surgeons Ireland, Dublin, Ireland

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 12期

关键词：

GLUT-1; rectal cancer; chemoradiotherapy; hypoxia; p53; TOTAL MESORECTAL EXCISION; COMPLETE PATHOLOGICAL RESPONSE; PREOPERATIVE CHEMORADIATION; TUMOR-REGRESSION; INTRINSIC MARKERS; HYPOXIA; CARCINOMA; RECURRENCE; SURVIVAL; APOPTOSIS;

D O I：

10.1002/ijc.24693

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification of predictive markers of response to chemoradiotherapy would improve patient selection and may allow response modification by targeting of specific pathways. The aim of this study was to determine whether expression of glucose transporter-1 (GLUT-1) and p53 in pretreatment rectal cancer biopsies was predictive of tumor response to chemoradiotherapy. Immunohistochemical staining for GLUT-1 and p53 was performed on 69 pretreatment biopsies and compared to tumor response in the resected specimen as determined by the tumor regression grade (TRG) scoring system. GLUT-1 expression was significantly associated with reduced response to chemoradiotherapy and increasing GLUT expression correlated with poorer response (p = 0.02). GLUT-1 negative tumors had a 70% probability of good response (TRG3/4) compared to a 31% probability of good response in GLUT-1 positive tumors. GLUT-1 may be a useful predictive marker of response to chemoradiotherapy in rectal cancer. (C) 2009 UICC

引用

页码：2778 / 2782

页数：5

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