Blood lipids in brain infarction subtypes

Background: Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI). Methods: In a cross-sectional study of 492 pairs of patients with a BI proven by MRI and matched hospital controls, we determined the blood levels of triglycerides, total, HDL and LDL cholesterol, and apolipoprotein A 1 and B, in the same centralized laboratory. We performed aetiological BI subtype classification. Results: Except for triglycerides, the risk of BI increased continuously with the lipid levels, without any heterogeneity between the main BI subtypes or the group on lipid-lowering therapy. The adjusted odds ratio per standard deviation in LDL cholesterol ( 0.93 mmol/ l) was 1.74 ( 95% confidence interval, 1.02-2.98) in atherothrombotic strokes ( n=109) and 2.71 ( 95% confidence interval, 1.60 - 4.55) in lacunar strokes ( n=105). Eighty percent of patients were above the ATP-III guideline threshold LDL cholesterol of 2.59 mmol/ l ( 100 mg/dl), with a major contribution of both atherothrombotic and lacunar stroke subtypes to this group. Conclusions: These findings suggest that blood lipids, particularly total and LDL cholesterol levels, are associated with all subtypes of BI, and that LDL above 2.59 mmol/ l is highly prevalent. Copyright (c) 2006 S. Karger AG, Basel