Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage

被引：8
作者：
Fontana, Diletta [1 ]
Gambacorti-Passerini, Carlo [1 ,2 ]
Piazza, Rocco [1 ,2 ,3 ]
机构：
[1] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, MB, Italy
[2] San Gerardo Hosp, Hematol & Clin Res Unit, Monza, Italy
[3] Univ Milano Bicocca, Bicocca Bioinformat Biostat & Bioimaging Ctr B4, Milan, Italy
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 02期
关键词：
ETNK1; phosphoethanolamine; mitochondria; reactive oxigen species; DNA damage;
D O I：
10.1080/23723556.2021.1877598
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently we showed that Ethanolamine Kinase 1 (ETNK1) mutations cause a decreased synthesis of phosphoethanolamine, and that phosphoethanolamine is able to modulate mitochondrial activity through competition with succinate for complex II. The decreased phosphoethanolamine concentration leads to increased mitochondria activity and reactive oxygen species production, which causes the accumulation of new mutations.
引用
收藏
页数：3
相关论文
共 10 条
  • [1] ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
    Fontana, Diletta
    Mauri, Mario
    Renso, Rossella
    Docci, Mattia
    Crespiatico, Ilaria
    Rost, Lisa M.
    Jang, Mi
    Niro, Antonio
    D'Aliberti, Deborah
    Massimino, Luca
    Bertagna, Mayla
    Zambrotta, Giovanni
    Bossi, Mario
    Citterio, Stefania
    Crescenzi, Barbara
    Fanelli, Francesca
    Cassina, Valeria
    Corti, Roberta
    Salerno, Domenico
    Nardo, Luca
    Chinello, Clizia
    Mantegazza, Francesco
    Mecucci, Cristina
    Magni, Fulvio
    Cavaletti, Guido
    Bruheim, Per
    Rea, Delphine
    Larsen, Steen
    Gambacorti-Passerini, Carlo
    Piazza, Rocco
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [2] Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia
    Fontana, Diletta
    Ramazzotti, Daniele
    Aroldi, Andrea
    Redaelli, Sara
    Magistroni, Vera
    Pirola, Alessandra
    Niro, Antonio
    Massimino, Luca
    Mastini, Cristina
    Brambilla, Virginia
    Bombelli, Silvia
    Bungaro, Silvia
    Morotti, Alessandro
    Rea, Delphine
    Stagno, Fabio
    Martino, Bruno
    Campiotti, Leonardo
    Caocci, Giovanni
    Usala, Emilio
    Merli, Michele
    Onida, Francesco
    Bregni, Marco
    Elli, Elena Maria
    Fumagalli, Monica
    Ciceri, Fabio
    Perego, Roberto A.
    Pagni, Fabio
    Mologni, Luca
    Piazza, Rocco
    Gambacorti-Passerini, Carlo
    [J]. HEMASPHERE, 2020, 4 (06):
  • [3] Recurrent ETNK1 mutations in atypical chronic myeloid leukemia
    Gambacorti-Passerini, Carlo B.
    Donadoni, Carla
    Parmiani, Andrea
    Pirola, Alessandra
    Redaelli, Sara
    Signore, Giovanni
    Piazza, Vincenzo
    Malcovati, Luca
    Fontana, Diletta
    Spinelli, Roberta
    Magistroni, Vera
    Gaipa, Giuseppe
    Peronaci, Marco
    Morotti, Alessandro
    Panuzzo, Cristina
    Saglio, Giuseppe
    Usala, Emilio
    Kim, Dong-Wook
    Rea, Delphine
    Zervakis, Konstantinos
    Viniou, Nora
    Symeonidis, Argiris
    Becker, Heiko
    Boultwood, Jacqueline
    Campiotti, Leonardo
    Carrabba, Matteo
    Elli, Elena
    Bignell, Graham R.
    Papaemmanuil, Elli
    Campbell, Peter J.
    Cazzola, Mario
    Piazza, Rocco
    [J]. BLOOD, 2015, 125 (03) : 499 - 503
  • [4] KENNEDY EP, 1956, J BIOL CHEM, V222, P193
  • [5] Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia
    Lasho, T. L.
    Finke, C. M.
    Zblewski, D.
    Patnaik, M.
    Ketterling, R. P.
    Chen, D.
    Hanson, C. A.
    Tefferi, A.
    Pardanani, A.
    [J]. BLOOD CANCER JOURNAL, 2015, 5 : e275 - e275
  • [6] SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
    Piazza, Rocco
    Magistroni, Vera
    Redaelli, Sara
    Mauri, Mario
    Massimino, Luca
    Sessa, Alessandro
    Peronaci, Marco
    Lalowski, Maciej
    Soliymani, Rabah
    Mezzatesta, Caterina
    Pirola, Alessandra
    Banfi, Federica
    Rubio, Alicia
    Rea, Delphine
    Stagno, Fabio
    Usala, Emilio
    Martino, Bruno
    Campiotti, Leonardo
    Merli, Michele
    Passamonti, Francesco
    Onida, Francesco
    Morotti, Alessandro
    Pavesi, Francesca
    Bregni, Marco
    Broccoli, Vania
    Baumann, Marc
    Gambacorti-Passerini, Carlo
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [7] Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
    Piazza, Rocco
    Valletta, Simona
    Winkelmann, Nils
    Redaelli, Sara
    Spinelli, Roberta
    Pirola, Alessandra
    Antolini, Laura
    Mologni, Luca
    Donadoni, Carla
    Papaemmanuil, Elli
    Schnittger, Susanne
    Kim, Dong-Wook
    Boultwood, Jacqueline
    Rossi, Fabio
    Gaipa, Giuseppe
    De Martini, Greta P.
    Di Celle, Paola Francia
    Jang, Hyun Gyung
    Fantin, Valeria
    Bignell, Graham R.
    Magistroni, Vera
    Haferlach, Torsten
    Pogliani, Enrico Maria
    Campbell, Peter J.
    Chase, Andrew J.
    Tapper, William J.
    Cross, Nicholas C. P.
    Gambacorti-Passerini, Carlo
    [J]. NATURE GENETICS, 2013, 45 (01) : 18 - U41
  • [8] Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
    Sabharwal, Simran S.
    Schumacker, Paul T.
    [J]. NATURE REVIEWS CANCER, 2014, 14 (11) : 709 - 721
  • [9] Phosphatidylethanolamine Deficiency in Mammalian Mitochondria Impairs Oxidative Phosphorylation and Alters Mitochondrial Morphology
    Tasseva, Guergana
    Bai, Helin Daniel
    Davidescu, Magdalena
    Haromy, Alois
    Michelakis, Evangelos
    Vance, Jean E.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (06) : 4158 - 4173
  • [10] Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type
    Zhou, Xiaolong Alan
    Louissaint, Abner, Jr.
    Wenzel, Alexander
    Yang, Jingyi
    Martinez-Escala, Maria Estela
    Moy, Andrea P.
    Morgan, Elizabeth A.
    Paxton, Christian N.
    Hong, Bo
    Andersen, Erica F.
    Guitart, Joan
    Behdad, Amir
    Cerroni, Lorenzo
    Weinstock, David M.
    Choi, Jaehyuk
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (11) : 2365 - 2376
1