Effect of biliary obstruction and pinealectomy on rat gastrointestinal crypt cell kinetics

被引：0

作者：

Callaghan, BD

机构：

来源：

MEDICAL SCIENCE RESEARCH | 1997年 / 25卷 / 10期

关键词：

pineal gland; bile; stathmokinetic technique; gastrointestinal cell kinetics;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Following pinealectomy, there is hyperproliferation of liver cells as well as small bowel crypt cells. Since an increased level of intraluminal bile is also associated with increased crypt cell proliferation, the possible role of an increase in bile production in the hyperproliferative effects of pinealectomy was investigated by combining pinealectomy with complete biliary obstruction. This procedure was not associated with any diminution in the hyperproliferative effects of pinealectomy in rats. It appears, therefore, that the hyperproliferative effect of pinealectomy on the crypts does not depend on changes in the level of intraluminal bile.

引用

页码：691 / 692

页数：2

共 9 条

[1]

BINDONI M, 1971, Archivio di Scienze Biologiche, V55, P3

[2] LIGATION OR EXTERNAL FISTULATION OF THE COMMON BILE-DUCT IN THE RAT .2. INTESTINAL DISACCHARIDASE ACTIVITIES [J].