Pandemic influenza: its origin and control

被引:29
作者
Laver, G
Garman, E
机构
[1] Univ Oxford, Dept Biochem, Lab Mol Biophys, Oxford OX1 3QU, England
[2] Barton Highway, Murrumbateman, NSW 2582, Australia
关键词
influenza; pandemic; neuraminidase inhibitors;
D O I
10.1016/S1286-4579(02)00013-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A "new" influenza virus will appear at some time in the future. This virus will arise by natural processes, which we do not fully understand, or it might be created by some bioterrorist. The world's population will have no immunity to the new virus, which will spread like wild-fire, causing much misery, economic disruption and many deaths. Vaccines will take time to develop and the only means of control, at least in the early stages of the epidemic, are anti-viral drugs, of which the neuraminidase inhibitors currently seem the most effective. (C) 2002 tditions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:1309 / 1316
页数:8
相关论文
共 40 条
  • [1] THE NEURAMINIDASE OF INFLUENZA-VIRUS
    AIR, GM
    LAVER, WG
    [J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1989, 6 (04): : 341 - 356
  • [2] BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
    Babu, YS
    Chand, P
    Bantia, S
    Kotian, P
    Dehghani, A
    El-Kattan, Y
    Lin, TH
    Hutchison, TL
    Elliott, AJ
    Parker, CD
    Ananth, SL
    Horn, LL
    Laver, GW
    Montgomery, JA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (19) : 3482 - 3486
  • [3] BURNET FM, 1948, J EXP BIOL MED SCI, V26, P410
  • [4] *CDC, 2002, MORT MORB WEEKL REP
  • [5] 3-DIMENSIONAL STRUCTURE OF A COMPLEX OF ANTIBODY WITH INFLUENZA-VIRUS NEURAMINIDASE
    COLMAN, PM
    LAVER, WG
    VARGHESE, JN
    BAKER, AT
    TULLOCH, PA
    AIR, GM
    WEBSTER, RG
    [J]. NATURE, 1987, 326 (6111) : 358 - 363
  • [6] GLYCOSYLATION AFFECTS CLEAVAGE OF AN H5N2 INFLUENZA-VIRUS HEMAGGLUTININ AND REGULATES VIRULENCE
    DESHPANDE, KL
    FRIED, VA
    ANDO, M
    WEBSTER, RG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (01) : 36 - 40
  • [7] Dowdle Walter R., 1997, Journal of Infectious Diseases, V176, pS69, DOI 10.1086/514180
  • [8] 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds
    Fanning, TG
    Slemons, RD
    Reid, AH
    Janczewski, TA
    Dean, J
    Taubenberger, JK
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (15) : 7860 - 7862
  • [9] Recombination in the hemagglutinin gene of the 1918 "Spanish flu"
    Gibbs, MJ
    Armstrong, JS
    Gibbs, AJ
    [J]. SCIENCE, 2001, 293 (5536) : 1842 - 1845
  • [10] NEURAMINIDASE - THE SPECIFIC ENZYME OF INFLUENZA VIRUS AND VIBRIO-CHOLERAE
    GOTTSCHALK, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1957, 23 (03) : 645 - 646