Adiponectin in essential hypertension

Adiponectin (ADPN), the gene product of apM1, is the most abundant secretory protein of adipose tissue in human plasma. Synthesis of this substance may be reduced in endothelial dysfunction and cardiovascular diseases in humans. We investigated the relationship between plasma ADPN, body mass index (BMI), fat mass (BIA) and renal function in 36 patients with uncomplicated essential hypertension. Plasma ADPN was higher in hypertensive patients than in normotensive subjects, but the difference just failed to reach-statistical significance (P = 0.06). Hypertensive men had significantly higher plasma ADPN than normotensive men (6.7 +/- 2.6 vs 4.8 +/- 2.0 mug/mL, 40%, P = 0.01). By contrast, the difference between hypertensive (8.5 +/- 3.9 mug/mL) and normotensive women (7.1 +/- 2.6 mug/mL) was not significant (20%). In hypertensive patients, plasma ADPN was inversely related to creatinine clearance and tended to be inversely related to serum insulin (r = -0.27) and HOMA-R index (r = -0.24). The relationship between plasma ADPN and renal function was confirmed in a multiple regression analysis which showed that creatinine clearance was the only independent predictor of plasma ADPN. Plasma ADPN in essential hypertension is dependent on sex and renal function. High levels in essential hypertensives may be the expression of a counter-regulatory response aimed at mitigating endothelial damage and cardiovascular risk associated with high arterial pressure.