The molecular diversity of glycosaminoglycans shapes animal development

被引：259
作者：
Bulow, Hannes E. [1 ]
Hobert, Oliver
机构：
[1] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA
[2] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2006年 / 22卷
关键词：
proteoglycans; heparan sulfate; chondroitin sulfate; dermatan sulfate; keratan sulfate; axon patterning;
D O I：
10.1146/annurev.cellbio.22.010605.093433
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.
引用
收藏
页码：375 / 407
页数：33
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