Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially

被引：16

作者：

Kang, Wonok ^{[1
,2
]}

Ju, Chanyang ^{[2
,3
]}

Joo, Jaesoon ^{[4
]}

Lee, Jiho ^{[2
,3
]}

Shon, Young-Min ^{[4
,5
]}

Park, Sung-Min ^{[1
,2
,3
,6
,7
,8
]}

机构：

[1] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 37673, South Korea

[2] Pohang Univ Sci & Technol, Med Device Innovat Ctr, Pohang 37673, South Korea

[3] Pohang Univ Sci & Technol, Dept Convergence IT Engn, Pohang 37673, South Korea

[4] Sungkyunkwan Univ, Biomed Engn Res Ctr, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea

[5] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Neurol, Seoul 06351, South Korea

[6] Pohang Univ Sci & Technol, Dept Elect Engn, Pohang 37673, South Korea

[7] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 37673, South Korea

[8] Yonsei Univ, Inst Convergence Sci, Seoul 03722, South Korea

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

DEEP BRAIN-STIMULATION; RAT MODEL; EPILEPTIFORM ACTIVITY; HIPPOCAMPAL-STIMULATION; CELL-DEATH; EXPRESSION; FREQUENCY; KAINATE; SUPPRESSION; GAD65;

D O I：

10.1038/s41467-022-35540-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here, in a rat model, we report a sequential narrow-field stimulation method for terminating seizures, while focusing stimulus energy at the spatially extensive hippocampal structure. The effects and regional specificity of this method were demonstrated via electrophysiological and biological responses. Our proposed modality demonstrates spatiotemporal preciseness and selectiveness for modulating the pathological target region which may have potential for further investigation as a therapeutic approach. Direct stimulation of the focus of a seizure may have potential for the treatment of epilepsy. Here the authors demonstrate in a rat model a sequential narrow-field stimulation method for terminating seizures.

引用

页数：18

共 111 条

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